红细胞参数筛查地中海贫血在产前检查中的应用价值  

The Value of Erythrocytic Parameters on Screening Thalassanemia in Prenatal Diagnosis

作　　者：许晓清[1] 吴方贵[1] 宋丹[1] 谭玉梅[1] 邱耀芳[1] 

机构地区：[1]广东省深圳市罗湖区人民医院,广东深圳518001

出　　处：《河北医学》2006年第3期198-201,共4页Hebei Medicine

摘　　要：目的:探讨红细胞平均体积(MCV)、平均红细胞血红蛋白量(MCH)、红细胞体积分布宽度(RDW)并结合HbA2、HbF检测结果在筛查围产期地中海贫血中的应用价值。方法:采用自动血细胞分析仪分别对120例地中海贫血患者、90例非地中海贫血者和60例对照者进行MCV、MCH、RDW测定,层析法测定HbA2,碱变性法测定HbF,并对结果作相关统计学分析。同时将部分筛查结果与地中海贫血基因诊断(PCR)结果进行比较,分析筛查方法的敏感度和特异度。结果:地中海贫血组MCV、MCH、RDW与对照组比较有显著性统计学意义(P<0.01);对照PCR结果,MCV、MCH、RDW诊断轻型地中海贫血的敏感性98.3%,特异性76.7%。结论:MCV、MCH、RDW可作为筛查围产期地中海贫血的有效指标,可疑者建议做进一步的检查,以明确诊断。Objective：To study the value of the tests of mean corpuscular volume （MCV） ,mean corpuscular hemoglobin （ MCH ）, red blood cell distribution width （ RDW ） and hemoglobin zones analyses for the diagnosis of halassemial. Methods：MCV,MCH and RDW were detected from 120 cases with thalassanemia, 90 cases with non -thalassanemia and 60 cases control by automatic blood analyzer system. HbA2 were detected by chromatography, HbF were analyzed by anti - base test, and compared with the test of gene diagnosis （ PCR test） in order to evaluating their sensitivity and specificity. Result： The results of MCV, MCH and RDW showed significantly different between the thalassanemia group and the control group （ P 〈 0.01 ）. The sensitivity and specificity of MCV, MCH , RDW was 98.8% and 73.6% comparing with PCR. Conclusion： MCV, MCH and RDW could use as significance level on screening thalassanemia in prenatal diagnosis.

关 键 词：红细胞参数 地中海贫血 

分 类 号：R714.5[医药卫生—妇产科学]