胃癌中p16^(INK4a)-CDK4-pRb通路蛋白表达异常  

ALTERATIONS OF pRb/CDK4/p16^(INK4a) PATHWAY IN GASTRIC CARCINOMAS

作　　者：赵英芳[1] 田新霞[2] 卢阳[3] 

机构地区：[1]包头医学院病理教研室,内蒙古包头014010 [2]北京大学医学部病理学系 [3]内蒙古医学院

出　　处：《内蒙古医学院学报》2005年第4期271-274,共4页Acta Academiae Medicinae Neimongol

摘　　要：目的:检测胃癌组织中p16INK 4a-CDK 4-pR b通路p16INK 4a、CDK 4、pR b蛋白表达状况,探讨蛋白表达与胃癌发生发展以及临床病理指标的关系。方法:采用免疫组织化学方法检测了胃癌组织中p16INK 4a、CDK 4、pR b蛋白表达。结果:10例正常胃黏膜中相应蛋白表达全部阳性,而肿瘤组织中p16INK 4a、pR b蛋白表达阳性率分别为54%(44/81)和90%(73/81),p16INK 4a蛋白表达显著低于正常组织(P=0.005),26%(21/81)的肿瘤组织中CDK 4过表达。p16INK 4a、pR b、CDK 4蛋白表达与肿瘤组织学类型、淋巴结转移及性别、年龄均无相关性。结论:p16INK 4a、CDK 4、pR b蛋白表达异常是胃癌细胞常见的分子事件,p16INK 4a-CDK 4-pR b细胞周期调控通路异常可能参与了胃癌的发生发展。Objective. To investigate the expression of p16^INK4a, CDK4 and Rb at protein level in gastric carcinomas, and the correlation with clinical and pathological parameters. Methods. A series of 81 gastric carcinomas and 10 normal gastric tissues were detected by immunohistochemistry. Results： Positive immunostaining for p16^INK4a and pRb protein was found in 54% （44/81） and 90% （73/81） of gastric carcinomas and 26%（21/81） of the tumors overexpress CDK4. The expression of p16^INK4a, pRb and CDK4 was not associated with differentiation status, sex, ages and lymph node metastasis. Conclusions. Alterations of pRb/p16^INK4a/CDK4 pathway is a common event in gastric carcinorhas and play a role in the development of gastric carcinomas.

关 键 词：胃肿瘤/病理学 P16^INK4A蛋白 CDK4蛋白 PRB蛋白 

分 类 号：R735.2[医药卫生—肿瘤]