TCLF方案治疗晚期胃癌的近期临床观察  

regimen of paclitaxel, cisplatin and 5-FU/folinic for patients with advanced gastric cancer

作　　者：曾江正[1] 苏群豪[1] 洪涛[1] 何志惠[1] 

机构地区：[1]海南医学院附属医院肿瘤内科,海南海口570102

出　　处：《海南医学》2006年第4期1-2,共2页Hainan Medical Journal

摘　　要：目的观察TCLF方案对晚期胃癌的近期疗效及毒副反应。方法20例患者,紫杉醇175mg/m2,d1;顺铂20mg/m2,d1～5;亚叶酸钙100mg/m2,d1～5;氟尿嘧啶500mg/m2,d1～5,28天/周期。2周期后评估临床疗效及毒副反应。结果20例晚期胃癌总有效率65%,其中完全缓解(CR)4例,部分缓解(PR)9例,临床受益有效率75%。主要毒副反应为白细胞减少、脱发及周围神经毒性。结论TCLF方案为晚期胃癌的有效化疗方案,毒性较低,可以接受。Objective To evaluate the efficacy and toxicity of combination chemotherapy with paclitaxel, cisplatin and 5-FU/folinie acid in patients with advanced gastric cancer. Methods Twenty patients with advanced gastric cancer received regimen of TCLF （175 mg/m^2 of paditaxe, intravenous infusion for 3h,day 1; 20mg/m^2 of cisplatin,day 1-5; 100 mg/m^2 of folinie acid, intravenous infusion for 2 h, day 1-5; 500 mg/m^2 of 5-fluorouracil, intravenous infusion for 4h, day 1-5 ）.Efficacy, and toxicities were evaluated after 2 cycles.A system to assess dinical benefit based on KPS, analgesic consumption, and weight gain was also used in this trial. Results Total response rate was 65.0% （13/20） with 4（20.0%） eases of complete remission （CR）, and 9 （45.0%） eases of partial remission （PR）. Fifteen （75.0%） patients attained a clinical benefit response.Leukopenia, loss of hair, peripheral neuropathy were main toxieities. Conclusions Regimen of TCLF may achieve a high response rate with tolerable toxicities in patients with advanced gastric cancer.

关 键 词：近期临床观察 晚期胃癌 方案治疗 周围神经毒性 毒副反应 LF方案 总有效率 完全缓解 白细胞减少 近期疗效 

分 类 号：R781.42[医药卫生—口腔医学] R735.2[医药卫生—临床医学]