甲壳糖/液晶复合膜的制备及其血液相容性研究  

Study on the hemocompatibility of chitosan/liquid crystal composite membranes

作　　者：易正戟[1] 谭凯旋[2] 澹爱丽[2] 何海[2] 周长忍[3] 

机构地区：[1]中国科学院广州地球化学研究所,广东广州510640 [2]南华大学建筑与资源环境学院,湖南衡阳421001 [3]暨南大学材料科学工程研究所,广东广州510632

出　　处：《浙江工业大学学报》2006年第2期123-126,共4页Journal of Zhejiang University of Technology

基　　金：国家自然科学基金项目(30170272);973项目子课题(G199054306)

摘　　要：用溶液共混浇铸法将胆甾型液晶(胆甾醇油烯基碳酸酯)和向列型液晶(4-乙氧基苄叉-4′-正庚基苯胺和4-正戊基-4′-氰基联苯)分散到甲壳糖溶液中制成三个系列的甲壳糖/液晶复合膜.借助偏光显微镜观察了材料表面的结构形态,研究了材料中液晶含量和成膜条件对复合膜表面结构形态的影响,用动态凝血实验、溶血实验和血小板粘附实验,对改性材料表面血液相容性做了评价.结果发现,只有当复合膜中的液晶含量超过30%时,复合膜表面呈现微相分离结构并表现出良好的血液相容性,且随液晶含量的增加而材料的抗凝血性能有明显的改善,尤其是复合膜表面吸附的血小板数量随液晶含量的增加而明显减少.Three series of polymeric composites were prepared by dispersing nematic liqid crystal （N-（-4-ethyoxybenzylidene）-4＇-heptylaniline and 4-pentyl-4＇-nitrile-biphenyl） and cholesteric liquid crystal（ cholesteryl oleyl carbonate） respectively into the chitosan solutions, The effect of liquid crystal content on the formation of liquid crystal phase was identified by the observation of optical polarization microscopy （OPM）. The results showed that the content of liquid crystal in composite membranes must be more than 30% in order to form micro-phase separation structure on the composite membrane surface. The hemocompatibility of modified biomaterials were evaluated by the dynamic blood-clotting , hemolysis and platelet-adhesion tests. The result show that those chitosan-liquid crystal composite membranes, in which the content of liquid crystal is more than 30%, appear to be beneficial in improving hemocompatibility. With the increase of liquid crystal content, the anticoagulation property was markedly improved and the amount of platelets adherent on the surface pronouncedly reduced.

关 键 词：甲壳糖 液晶 复合膜 微相分离结构 抗凝血性能 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业]