DNA损伤与肿瘤发生的研究进展  

Advances in research on DNA damage response in tumorigenesis

作　　者：谢成英(综述)[1] 蔡育军[1] 丁健(审校)[1] 

机构地区：[1]中国科学院上海药物研究所,国家新药研究重点实验室肿瘤药理组,上海201203

出　　处：《中国癌症杂志》2006年第4期313-317,共5页China Oncology

基　　金："抗肿瘤药物临床前药效学关键技术及平台研究"滚动课题(2004AA2Z3811)。

摘　　要：生物体基因组时刻都暴露在体内外各种应激因素的作用下,即使在非常健康的细胞其基因组DNA的完整性也持续受到威胁。DNA在细胞内外各种因素的作用下可不断产生损伤,如体内代谢过程中产生的自由基和其它活性化合物,DNA在复制和重组过程中自发的错误;环境中的紫外线和离子辐射以及一些化学物质均能损伤DNA。细胞能通过周期阻滞修复DNA或者细胞凋亡对DNA损伤产生反应。细胞对DNA损伤反应的异常将导致肿瘤的发生。本文综述当前对DNA损伤修复和凋亡的分子调控以及它与肿瘤发生的研究进展。The genomic DNA of the organism is often exposed to many kinds of stress factors. The integrity of genomic DNA is constantly under threat, even in perfectly healthy cells. DNA damage can result from stochastic errors in the replication or recombination of DNA, or from the action of endogenous free radicals and active compounds, as well as from environmental stress factors like UV and ion radiation. Cells can be arrested at some phase of the cell cycle to facilitate DNA repair or induced into apoptosis after DNA damage. Carcinogenesis could result from the abnormal response of cells to DNA damage. This review describes current understanding of the molecular control of DNA damage-induced repair and apoptosis with particular attention to its role in tumorigenesis.

关 键 词：DNA损伤 DNA修复 细胞周期阻滞 细胞凋亡 肿瘤发生 

分 类 号：R730.1[医药卫生—肿瘤]