凋亡抑制因子Survivin在小鼠内耳发育中的作用  

Role of Survivin,An Apoptosis Inhibitor,in Development of Inner Ears of Mice

作　　者：李春晖[1] 杜宝东[1] 孙阳[2] 雷爱军[1] 李贵才[2] 马忠恕[1] 

机构地区：[1]吉林大学第一临床医院耳鼻咽喉头颈外科,长春130021 [2]长春生物制品研究所,长春130062

出　　处：《中国生物制品学杂志》2006年第2期162-163,共2页Chinese Journal of Biologicals

摘　　要：目的探讨凋亡抑制因子Survivin在小鼠内耳发育中的作用.方法应用HE染色观察小鼠内耳发育形态演变过程、免疫组织化学方法检测Survivin在小鼠12～17 d胚胎、生后14 d内乳鼠内耳的表达情况.结果Survivin在听泡上皮增殖期表达最广泛,在分化成熟期表达逐渐增强,而范围减小.结论Survivin参与小鼠内耳发育,在细胞增殖与分化、器官塑形过程中起一定的作用,为探索毛细胞再生和耳聋防治奠定基础.Objective To explore the role of Survivin,an apoptosis inhibitor,in the development of inner ears of mice. Methods Observe the morphological change of inner ear of mice during development by HE staining, and determine the expressions of Survivin in 12-17-day-old ratine embryo and the inner ears of mice within 14 days after birth by immunohistochemieal method. Results Survivin was widely expressed during the proliferation period of otic vesicle epidermis ,and its expression level increased gradually during the differentiation and maturation periods of cochlea and vestibule. However, the range of expression of Survivin decreased during the three periods. Conclusion Survivin played an important role in the development of inner ears of mlce, including the proliferation and differentiation of cells and the mold of organ. It laid a foundation of further study on the regeneration of hair cells and the prevention and treatment of deaf.

关 键 词：SURVIVIN 凋亡抑制因子 内耳 发育 小鼠 

分 类 号：R730[医药卫生—肿瘤]