Causal role of Helicobacter pylori infection in gastric cancer: An Asian enigma  

作　　者：Kartar Singh Uday C Ghoshal 

机构地区：[1]Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences

出　　处：《World Journal of Gastroenterology》2006年第9期1346-1351,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by grants from the Indian Council of Medical Research, No. 5/4/3-5/03/99-NCD-Ⅱ

摘　　要：Helicobacter pylori （H pylori） has been etiologically linked to gastric cancer. H pylori infection is more frequent in less developed Asian countries like India, Bangladesh, Pakistan, and Thailand and is acquired at early age than in more developed Asian countries like Japan and China. Frequency of gastric cancer, however, is very low in India, Bangladesh, Pakistan and Thailand compared to that in Japan and China. Similar enigma has been reported from Africa as compared to the West. Seroprevalence of HpyloN infection in adult populations of India, Bangladesh, Pakistan and Thailand varies from 55% to 92%. In contrast, seroprevalence of H pylon in Chinese and Japanese adults is 44% and 55%, respectively. Annual incidence rate of gastric cancer in India, Bangladesh, and Thailand is 10.6, 1.3, 7.1 per 100 000 populations, respectively; in contrast, that in China and Japan is 32-59 and 80-115 per 100 000 populations, respectively. Several studies from India failed to show higher frequency of H pylori infection in patients with gastric cancer than controls. Available evidences did not support difference in H pylori strains as an explanation for this enigma. Despite established etiological role of H pylon, situation is somewhat enigmatic in Asian countries because in countries with higher frequency of infection, there is lower rate of gastric cancer. Host＇s genetic makeup and dietary and environmental factors might explain this enigma. Studies are urgently needed to solve this issue.Helicobacter pylori (H pylori ) etiologically 被连接了到胃的 cancer.H pylori 感染在象印度，孟加拉国，巴基斯坦，和泰国一样的少些发达的亚洲国家是更经常的并且比在更多的发达亚洲人国家喜欢日本和中国在早年龄被获得。然而，胃的癌症的频率在与那相比的印度，孟加拉国，巴基斯坦和在日本和中国的泰国是很低的。类似的谜作为与韦斯特相比从非洲被报导了。在印度，孟加拉国，巴基斯坦和泰国的成年人口的 H pylori 感染的 Seroprevalence 从 55% ～ 92% 变化。相反，在中国、日本的成年人的 H pylori 的 seroprevalence 分别地是 44% 和 55% 。在印度，孟加拉国，和泰国的胃的癌症的年度发生率是 10.6， 1.3， 7.1 每 100,000 张人口分别地；相反，那分别地每 100,000 张人口在中国和日本是 32-59 和 80-115。来自印度的几研究没能比控制与胃的癌症在病人显示出 H pylori 感染的高频率。可得到的证据没作为对这个谜的解释在 H pylori 紧张支持差别。尽管有 H pylori 的确定的病因学的角色，因为，状况在亚洲国家是有点神秘的在有感染的高频率的国家，有胃的癌症的更低的率。主人的基因组成和饮食、环境的因素力量解释这个谜。研究着急地被需要解决这个问题。

关 键 词：Stomach cancer Helicobacter pylori Tropical countries CARCINOGENESIS Infectious diseases 

分 类 号：R735.2[医药卫生—肿瘤]