选择性环氧合酶-2抑制剂的研究现状及进展  

Advances in selective COX-2 inhibitors

作　　者：曾翼[1] 徐进宜[1] 吴晓明[1] 华维一[1] 

机构地区：[1]中国药科大学药物化学教研室,南京210009

出　　处：《中国新药杂志》2006年第6期410-415,共6页Chinese Journal of New Drugs

基　　金：教育部优秀青年教师基金项目(2003355);江苏省自然科学基金项目(DK2004109)

摘　　要：非甾体抗炎药(NSAIDs)是临床上应用非常广泛的一类药物,但严重的不良反应使其应用受到很大限制。研究已经发现,NSAIDs对炎症的有效治疗源于其对环氧合酶-2(COX-2)的抑制作用。综述了选择性COX-2抑制剂作用的分子基础、构效关系及其目前研究开发的现状和最新进展。Nonsteroidal anti-inflammatory drugs （NSAIDs） are among the most widely prescribed medications. However, part of NSAIDs were limitedly used due to their significant side effects. It has been found that the therapeutic effects of Some NSAIDs are associated with the COX-2 inhibition. In this paper, the molecular basis, structure-activity relationships as well as the advances in R＆D of selective COX-2 inhibitors were reviewed.

关 键 词：选择性环氧合酶-2抑制剂 非甾体抗炎药 构效关系 

分 类 号：R971.1[医药卫生—药品]