阻塞性黄疸鼠肠粘膜免疫功能的变化  

The effect of obstructive jaundice on gut immune cellularity

作　　者：卢晓明[1] 肖谷欣[1] 田元[1] 

机构地区：[1]同济医科大学附属协和医院普通外科,武汉430022

出　　处：《中华实验外科杂志》1996年第4期195-196,共2页Chinese Journal of Experimental Surgery

摘　　要：SD大鼠分为阻塞性黄疸组和对照组,胆总管结扎制造阻塞性黄疸模型,以胆汁外引流组为对照。制模后2周,检测小肠液分泌型IgA浓度、肠粘膜内淋巴细胞体外刺激转化能力、粘膜固有层淋巴细胞亚群。结果发现;阻黄鼠肠液分泌型IgA浓度和肠粘膜内淋巴细胞转化能力明显降低;粘膜固有层含IgA浆细胞、CD_4^+和CD_8^+淋巴细胞数目明显减少。结果表明阻黄时肠粘膜免疫功能抑制。The purpose of the study was to evaluate the effect of obstructive jaundice on gut immune cellularity. SD rats were divided into two groups. Obstructive jaundice was induced by common bile duct ligation in experimental group. The animals receiving bile external drainage served as control. Secretory IgA(S-IgA) concentration in intestinal solution, lymphoproliferative ability to in vitro stimulation, lymphocytes subgroup in gut lamina propria were assayed 14 days after induction of obstructive jaundice. The results indi cated that S-IgA concentration in intestinal solution, lymphoproliferative ability to stimulation were decreased significantly compared to control. Immuno-histochemical founding indicated that IgA+ plasma cells, CD4+ and CD8 +lymphocytes were depleted markedly compared to control. It is concluded that gut immune cellularity is inhibited deeply in animals with obstructive jaundice.

关 键 词：阻塞性黄疸 肠粘膜 免疫功能 

分 类 号：R575.03[医药卫生—消化系统]