异体脱钙骨复合自体红骨髓修复下颌骨缺损  

Experimentalstudyonrepairofmandibulardefectbyalogenicdecalcifiedbonecompundedwithau┐togeneicbonemarrowinrabbits

作　　者：李月玲[1] 杨彦昌[1] 闫丽华[1] 

机构地区：[1]中国医科大学口腔医院

出　　处：《中华口腔医学杂志》1996年第4期232-234,共3页Chinese Journal of Stomatology

摘　　要：为研究异体脱钙骨与自体红骨髓在修复下颌骨缺损中的作用，作者在２０只成年家兔双侧下颌骨下缘造成骨缺损，将异体脱钙骨加自体红骨髓复合移植于骨缺损处。通过术后４、１４、２８、４２、５６、８４天的Ｘ线平片评分，９９Ｔｃ－ＰＹＰ骨扫描计数，组织学和组织化学染色及透射电镜观察复合移植的诱导成骨过程及其对骨缺损愈合的影响。结果：Ｘ线平片观察Ｐ＜０．０５，骨扫描计数Ｐ＜０．０５，组织学、组织化学和电镜观察实验组新骨形成的量明显优于对照组。说明复合移植是通过诱导机制形成新骨，它可促进和加速骨愈合。Twentyadultrabbitswereusedinourexperiment.Thebonedefectsweremadeatthelowerborderofthebilateralmandible.Acompoundbonegraft(alogenicdecalcifiedbonewithautogeneicbonemarow,ADB)wasimplantedintherightbonedefectastheexperimentalgroup.Theleftmandiblewastakenasthecontrolgroupandautogeneiccancelousbonewasgrafted.TheprocessofnewboneformationwasevaluatedbyX-rayplainfilm,99Tc-PYPScintigraphy,histolog-icalandhistochemical,andtransmmisionelectronicmicroscopeexaminations.Theresultsdemon-stratedhistogicalythatADBinducednewboneformation.Thequantityofnewboneproducedbycompoundbonegraftintheexperimentalgroupwasmuchmorethanthatincontrolgroup(P<0.05).Thecompoundbonegraftcanpromoteandacceleratebonedefecthealing.

关 键 词：下颌骨缺损 修复 红骨髓 骨移植 

分 类 号：R782.405[医药卫生—口腔医学]