人格障碍遗传度双生子研究  

A twin study of personality disorder heritability

作　　者：纪文艳[1] 胡永华[1] 黄悦勤[2] 曹卫华[1] 吕筠[1] 秦颖[1] 逄增昌[3] 汪韶洁[3] 李立明[1] 

机构地区：[1]北京大学公共卫生学院,100083 [2]北京大学精神卫生研究所 [3]青岛市疾病预防控制中心

出　　处：《中华流行病学杂志》2006年第2期137-141,共5页Chinese Journal of Epidemiology

基　　金：中华医学基金资助项目(01-746)

摘　　要：目的利用双生子人群估计人格障碍的遗传度.方法采用人格障碍诊断问卷第4版（PDQ-4）作为筛查工具,在知情同意的基础上,对青岛市20～70岁的成人双生子进行问卷调查.其中已知卵性鉴定结果的双生子共324对,对其中性别相同的242对双生子进行结构方程模型拟合,计算人格障碍的遗传度.结果人格障碍总评分遗传度为68.26%（60.26～74.78）,A组评分遗传度为59.00%（49.22～67.17）,B组评分遗传度为64.99%（56.24～72.16）,C组评分遗传度为63.66%（54.72～71.02）.分裂型、自恋型和依赖型有显著的遗传效应,遗传度分别为49.96%（37.94～60.14）、52.89%（41.85～62.24）和68.87%（60.80～75.40）.戏剧型不受遗传因素作用,共同环境效应显著,占总变异方差的54.08%（44.50～62.43）.结论人格障碍主要受遗传因素决定,这些结果将会对人格障碍的进一步研究提供依据.Objective To calculate heritabilities of personality disorders（PDs） in twin population. Methods Based on informed consent, we used Personality Diagnostic Questionnaire（fourth-version） as our screening tool to study the adult twins（aged 20-70 years） in Qingdao city. There were 324 twin pairs whose zygosity had been determined. Structural equation modeling was used to estimate the heritabilities by 242 same-sex twin pairs. Results The best-fitting models yielded a heritability of 68.26 % （60.26-74.78） of overall PDs, 59.00 % （49.22-67.17） of cluster A, 64.99 % （56.24-72.16） of cluster B, and 63.66 % （54.72-71.02） of cluster C. There were significant genetic effects for schizotypal, narcissistic and dependent, explaining 49.96 % （37.94-60.14）, 52.89 % （ 41.85-62.24 ） and 68.87 % （ 60.80-75.40 ） of the variance respectively. No genetic effects were found on Histrionic, but common environmental effect accounted for 54.08 % （44.50-62.43） of the total variances. Conclusion PD was mainly determined by genetic factor. These findings may provide evidence for future research on PD.

关 键 词：双生子 人格障碍 遗传度 

分 类 号：R749.92[医药卫生—神经病学与精神病学]