出生前接触酒精对婴儿视力的影响  

Effects of prenatal alcohol exposure on infant visual acuity

作　　者：Carter R.C Jacobson S.W Molteno C.D. 张磊 

机构地区：[1]Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, 2751 E. Jefferson, Detroit, MI 48207, United States,Dr.

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第3期8-9,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Objective: To examine the effects of prenatal alcohol exposure ascertained prospectively on infant visual acuity across a range of exposures and factors that mediate or moderate these effects. Study design: Infant visual acuity was examined in 131 Cape Coloured (mixed ancestry)maternal-infant pairs in Cape Town, South Africa. Drinking patterns were documented by maternal reporting during pregnancy. Grating acuity was assessed with Teller Acuity Cards (TAC) at 6.5 months after term. Data were analyzed by correlation, multiple regression, and analysis of variance. Results: Greater average daily prenatal alcohol exposure was related to poorer acuity, as indicated by lower TAC scores. The effect of alcohol on acuity was significant primarily for infants born to mothers ≥30 years of age at delivery, in comparison to infants born to younger mothers. This effect was not mediated by gestational age or birth size or attributable to alcohol-related neurocognitive deficits. Conclusions: This study linked prenatal alcohol exposure ascertained prospectively to poorer visual acuity in infancy. The results are consistent with clinical and animal evidence of alcohol-related disruption of the visual system.To examine the effects of prenatal alcohol exposure ascertained prospectively on infant visual acuity across a range of exposures and factors that mediate or moderate these effects. Study design： Infant visual acuity was examined in 131 Cape Coloured （mixed ancestry）maternal-infant pairs in Cape Town, South Africa. Drinking patterns were documented by maternal reporting during pregnancy.

关 键 词：Teller视力卡 出生前 婴儿 酒精 前瞻性研究 母婴配对 饮酒情况 变量分析 多元回归 饮酒量 

分 类 号：R774.1[医药卫生—眼科] R321.5[医药卫生—临床医学]