抗结核药所致肝损害的发生机制及影响因素  

On Mechanism and Factor of Liver Dysfunction by Anti-tuberculosis Drugs

作　　者：郭虹[1] 李环[1] 李淑芬[1] 严慧毅[1] 

机构地区：[1]北华大学医学院,吉林吉林132013

出　　处：《北华大学学报（自然科学版）》2006年第2期159-161,共3页Journal of Beihua University（Natural Science）

摘　　要：药物性肝损害是抗结核治疗药物中最常见的毒副作用之一，其发生机理与抗结核药物引起的肝细胞变性坏死等有关．乙肝病毒携带、个体免疫状态、既往肝病史等均是影响药物性肝炎的主要因素．为避免结核病人发生药物性肝损害，治疗前须先检测乙肝标志物，并密切观察其肝功能的变化，以减轻抗结核治疗中的药物性肝损害．The pharmacology damage to liver is very common in poison byLeffection in anti-tuberculosis drugs. The reason why this happened have some relation in dead liver cell. Carrying Hepatits B virus, the condition of immunity and history of HIV are the main factors to affect pharmacology liver. Hepatits B virus marker must be determined and the change of liver function must be observed before treatment in order to avoid pharmacology damage to liver, which can alleviate pharmacology damage to liver in curing the tuberculosis.

关 键 词：结核 药物性肝损害 乙肝标志物 

分 类 号：R575[医药卫生—消化系统]