危重患儿血清细胞因子C反应蛋白乳酸测定及临床意义  

The detection and clinic value of cytokine、c-react protein and lactate in critically ill children

作　　者：高宗勋[1] 雷淑琴[1] 魏艳红[1] 宋义琴[1] 李爱珍[1] 刘艳[1] 王志华[1] 王会芳[1] 

机构地区：[1]河北省保定市儿童医院,河北保定071051

出　　处：《中国小儿急救医学》2006年第2期134-136,共3页Chinese Pediatric Emergency Medicine

摘　　要：目的研究危重患儿血清白细胞介素-1β(IL-1β)、IL-6、肿瘤坏死因子-α(TNFα-)、C反应蛋白(CRP)、乳酸(LAC)的变化。方法检测48例危重患儿,20例非危重患儿血清IL-1β、IL-6、TNFα-、CRP、LAC的水平。结果危重患儿血清IL-1β、IL-6、TNFα-、CRP、LAC的水平明显高于非危重患儿,且危重患儿中SIRS组明显高于非SIRS组、感染组明显高于非感染组,差异有显著性。结论血中IL-1β、IL-6、TNFα-、CRP、LAC参与危重病的发生发展过程,可作为危重病发生多器官功能不全的警示参数及诊断指标,并可预测危重患儿的预后及转归。Objective To study the change of interleukin-1β（IL-1β）, IL-6, tumor necrosis factor-α （TNF-α）, CRP, LAC in the serum of critically ill children. Methods The levels of IL-1β, IL-6, TNF-α, CRP, LAC in 48 critically ill children and 20 children without critical illness were detected. Results The levels of IL-1β, IL-6, TNF-α, CRP in chidren with critical illness were higher than that in those without critical illness, the group with SIRS was higher than that without SIRS and the group with infection was higher than that without infection respectively, the differences were significant. Conclusion IL-1β, IL-6, TNF-α, CRP, LAC are related to the development and deterioration of critical illness. They can be regarded as alarm sterms or dig- nosis standard of MOF, and be used to evaluate the prognosis.

关 键 词：危重症 细胞因子 C反应蛋白 乳酸 

分 类 号：R720.597[医药卫生—急诊医学] R329.26[医药卫生—儿科]