唑来膦酸合并放射治疗骨转移癌临床研究  

CLINICAL STUDY OF METASTATIC BONE TUMOUR TREATED WITH ZOLEDRONIC ACID COMBINED WITH RADIOTHERAPY

作　　者：曹辉[1] 单硕[1] 周光[1] 王海龙[1] 翁欣然[1] 郑汉光[2] 

机构地区：[1]温州市第二人民医院放疗科,温州325000 [2]浙江省中西医结合医院疼痛科

出　　处：《中国疼痛医学杂志》2006年第1期14-17,共4页Chinese Journal of Pain Medicine

基　　金：温州市医药卫生科研项目(2005047)

摘　　要：目的:观察唑来膦酸联合放射治疗对骨转移癌疼痛的疗效及不良反应。方法:98例骨转移癌患者随机分成观察组(51例)和对照组(47例)。观察组静滴唑来膦酸4 mg加局部放疗37.5GY/15F,之后再静滴唑来膦酸4 mg;对照组则单纯行放疗。结果:观察组与对照组止痛有效率分别为88.2%和74.5%(P>0.05),多发骨转移癌疼痛病灶研究组与对照组止痛有效率分别为86.5%和67.6%(P<0.05),随访2个月后观察组与对照组止痛有效率分别为86.3%和66.0%(P<0.05)。结论:唑来膦酸联合放射治疗骨转移癌疼痛疗效优于单纯放疗,唑来膦酸副作用轻。Objective： To evaluate the efficacy of zoledronic acid combined with radiotherapy to relieve pain due to metastatic bone tumours. Methods： 98 patients with metastatic bone tumours were randomly divided into observation group （51 cases） and control group （47 cases）. Observation group was treated with zoledronic acid （4 mg, i. v. ） and combined with radiotherapy （ DT 37.5GY/15F） ; control group was only treated by radiotherapy. Results： The effective rate of the observation group and control group was 88.2% and 74.5%, respectively （ P 〉 0.05 ）. For multiple focus of bone metastasis tumour pain, the effective rate of observation group was 86.5% , while the control group was 67.6% （P 〈0.05） ; after two-month follow-up, the effective rate of the observation group and control group was 86.3% and 66. 0%, respectively （P 〈 0.05 ）. Conclusion ： Acid combined with radiotherapy is effective to relieve pain from metastatic bone tumours, and the side effect was mild.

关 键 词：唑来膦酸 放射治疗 骨转移癌 疼痛 

分 类 号：R738.1[医药卫生—肿瘤]