糖苷合成研究（Ⅶ）──1－O－β－D－芳酰基－2，3，4－三－O－乙酰基葡萄糖醛酸甲酯的合成及其生物学活性  

STUDIES ON THE SYNTHESIS OF GLYCOSIDES (Ⅶ )-THE SYNTHESIS OF METHYL 1-O-ARYLCARBONYL -2, 3, 4-TRI-O-ACETYL-β-D-GLUCOPYRANURONATE AND THEIR ANTTUMOR ACTIVITIES

作　　者：孙昌俊 王义贵 李洪祥 戚聿新 陈再成 薛鹏[1] 

机构地区：[1]武汉大学化学系

出　　处：《山东大学学报（自然科学版）》1996年第3期327-331,共5页Journal of Shandong University(Natural Science Edition)

摘　　要：以相转移催化法使２，３，４－三－Ｏ－乙酰基－１－溴－１－脱氧－α－Ｄ－葡萄糖醛酸甲酯与取代呋喃甲酸，取代苯甲酸反应，合成了八个糖酯类化合物，其中六个未见文献报道，所有产物的结构经ＩＲ，１ＨＮＭＲ，元素分析等所证实，并初步测定了其抗肿瘤活性．A series of compounds:methyl 1-O-arylcarbonyl-2, 3, 4-tri-O-acetyl-β-D-glucopyranuronate 3a￣3c,5a￣5e had been synthesized by the reaction of furancarboxylic acid 1a￣ 1c,substitutied benzoic acid 4a￣4d,pyrimidin carboxylic acid 4e and methyl 2, 3, 4-tri-O-acetyl-1-bromo-ldeoxy-α -D-glupyranuronate 2 under phase transfer catalysis. 3a￣3c and 5a￣5c are new compounds. Their structures were confirmed by IR,1HNMRand elementary analysis. Preliminary results of the in vitro tests on HL-60 tumor cellsshowed that the inhibitory ratio of 3a was 50. 8%, 3b was 47. 0% and sc was 32. 5 %.

关 键 词：糖酯 合成 糖苷 葡萄糖醛酸甲酯 生物活性 

分 类 号：O629.13[理学—有机化学] R979.1[理学—化学]