妇科肿瘤患者外周血淋巴细胞亚群研究  

Lymphocyte Subsets in Peripheral Blood of Patients withGynecologic Tumor

作　　者：李广太[1] 张士伟[1] 宋学茹[1] 钟述猷[1] 刘政[1] 尉建华 杨金富 米保香 

机构地区：[1]天津医科大学总医院妇产科,天津医科大学总医院免疫室,河南省安阳县人民医院

出　　处：《中国肿瘤临床》1996年第7期504-508,共5页Chinese Journal of Clinical Oncology

摘　　要：应用抗人淋巴细胞单克隆抗体免疫荧光技术检测２０９例妇科肿瘤患者的外周血淋巴细胞亚群，发现妇科恶性肿瘤患者的ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８比值明显下降，而ＣＤ８明显增加；且这些改变在早期即已出现，随肿瘤负荷的增加而愈加明显。当给予适当治疗减少肿瘤负荷后，这些变化逐渐恢复；而一旦出现复发，上述各项指标又明显改变。因而上述检测指标可考虑作为临床诊断、观察疗效、监测复发和预后的参考。The peripheral blood lymphocyte(PBL)subsets in 209 patientswith gynecologic tumors were investigated by using anti-human lymphocyte monoclonal antibody and indirect immunofluorescence technique.In patients with gynecologic malignancy,CD3,CD4 and CD4/CD8 ratio were remarkably decreased,butCD8 was markedly increased(P<0.0001).All the significant changes were evidentat the early stage of cancer.With the progress of disease the changes became moreand more evident.When tumor burden was reduced after treatment the immunefunction of the patients restored gradually.Upon recurrence these parameters deteriorated.Therefore,the determination of PBL subsets would help in making clinicaldiagnosis,in the evaluation of the effect of therapy,monitoring recurrence,and inpredicting the prognosis.

关 键 词：妇科肿瘤 淋巴细胞亚群 免疫荧光技术 

分 类 号：R737.3[医药卫生—肿瘤]