Effect of 5-HT1 agonist (sumatriptan) on anorectal function in irritable bowel syndrome patients  

作　　者：Agata Mulak Leszek Paradowski 

机构地区：[1]Department of Gastroenterology and Hepatology Wroclaw Medical University,Wroclaw,Poland

出　　处：《World Journal of Gastroenterology》2006年第10期1591-1596,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by the grant from GlaxoSmithKline Pharmaceuticals S.A.

摘　　要：AIM： To evaluate the effect of sumatriptan, a selective 5-HT1 agonist, on anorectal function in irritable bowel syndrome （IBS） patients. METHODS： Twenty-two IBS patients selected according to the Rome II criteria （F 15, M 7; mean age 29.3±6.8, range 22-44 years） were examined. The study was blind, randomized and placebo-controlled with a crossover design. Anorectal manometry and rectal balloon distension test were performed before and after the administration of placebo and sumatriptan. RESULTS： The administration of sumatriptan caused a significant increase in the resting anal canal pressure from 9.2±2.0 kPa to 13.1±3.3 kPa （P〈0.0001） connected with the increase in the anal sphincter length and high pressure zone. After sumatriptan injection a remarkable increase in the threshold for the first sensation from 27±9 mL to 34±12 mL （P〈0.05） and urge sensation from 61±19 mL to 68±18 mL （P〈0.01） was observed. Sumatriptan did not affect either the volume evoking the rectoanal inhibitory reflex or the results of the straining test. CONCLUSION： 5-HT1 receptors participate in the regulation of anorectal function. Elucidation of the role of 5-HT1 receptors in the pathophysiological mechanisms of IBS may have some therapeutic implications.瞄准：评估 sumatriptan 的效果，选择 5-HT1 收缩筋，在在急躁的肠症候群(IBS ) 的肛门直肠的功能上病人。方法：根据罗马 II 标准选择的 22 个 IBS 病人(F 15， M 7；吝啬的年龄 29.3+/-6.8，范围 22-44 年) 被检验。学习是盲目的，使随机化并且与一个转线路图案控制安慰剂。肛门直肠的测压法和直肠的汽球扩张测试在安慰剂和 sumatriptan 的管理前后被执行。结果：从 9.2+/-2.0 kPa 在休息肛管压力引起重要增加到 13.1+/-3.3 kPa (P<0.0001 ) 的 sumatriptan 的管理随肛门括约肌长度和高压力地区的增加连接了。在 sumatriptan 注射以后，为到 34+/-12 mL (P<0.05 ) 的从 27+/-9 mL 的第一种感觉和到 68+/-18 mL (P<0.01 ) 的从 61+/-19 mL 的冲动感觉的阀值的显著增加被观察。Sumatriptan 也没影响唤起肛门禁止的反射或拉紧的结果测试的书籍的右页的体积。结论：5-HT1 受体参予肛门直肠的功能的规定。在 IBS 的 pathophysiological 机制的 5-HT1 受体的角色的说明可以有一些治疗学的含意。

关 键 词：SUMATRIPTAN 5-HT receptors Irritable bowel syndrome  Anorectal function 

分 类 号：R574[医药卫生—消化系统]