含长春瑞宾联合方案治疗复发卵巢癌28例分析  

Navelbine Combined with other Anticancer Drug in 28 Cases of Relapsed Ovarian Carcinoma

作　　者：王志美 徐洋 何珩 

机构地区：[1]青岛肿瘤医院,山东青岛266042

出　　处：《实用妇产科杂志》2006年第3期161-162,共2页Journal of Practical Obstetrics and Gynecology

摘　　要：目的研究长春瑞宾(NVB)与表柔比星(EPI)或卡铂(CBP)联合治疗复发卵巢癌的疗效和毒性反应。方法对初次治疗使用PC方案的18例患者采用NVB与EPI联合治疗,另10例初次治疗采用CAP方案的患者采用NVB与CBP联合治疗。结果完全缓解2例,部分缓解9例,总有效率39.3%,毒性反应以骨髓抑制、脱发、局部反应为重。胃肠反应及其他毒性轻微。结论NVB与EPI或CBP联合应用治疗复发卵巢癌疗效肯定,毒副反应轻微,值得临床推广使用。Objective：To investigate the therapeutic effect and toxicity of Navelbine （NVB） combined with Epirubicn （EPI） or Carboplatin （CBP） in anticancer treatment on relapsed ovarian carcinoma. Methods：18 patients who had been treated with cisplatin were treated with NVB and EPI this time. Ten other patients who had been treated with CAP were treated with NVB and CBP. Results：Among the 28 patients,there are 2CR,9 PR,13 SO and 4PD. With a total effective incidence of 39.3%. Marrow suppression, alopecia and phlebitis were the most common toxicities. The incidence of Leukopenia was 80.4%, alopecia 53.9%, phlebitis 23.5 %, gastrointestinal and other toxicity were mild.Conclusions：Combination of NVB and EPI （or CBP） was very effective intreating ovarian carcinoma with mild toxicity, and ,should be introduced and recommended.

关 键 词：复发卵巢癌 长春瑞宾 表柔比星 卡铂 

分 类 号：R737.31[医药卫生—肿瘤]