使用多肿瘤标志物蛋白质芯片诊断系统(C-12)检测胃癌的临床价值  

The clinical value of multi-tumor markers protein chip assistance diagnostic system in the diagnosis of gastric cancer

作　　者：余剑英[1] 

机构地区：[1]中南大学湘雅医院核医学科,湖南长沙410008

出　　处：《中国医师杂志》2006年第3期317-319,共3页Journal of Chinese Physician

摘　　要：目的研究多肿瘤标志物蛋白芯片诊断系统用于胃癌的诊断价值。方法用多肿瘤标志物蛋白芯片诊断系统检测50例正常人,70例胃良性疾病及80例胃癌患者血清中十二种常见的肿瘤标志物:甲胎蛋白(AFP),癌胚抗原(CEA),神经元特异性烯醇化酶(NSE),糖原125(CA125),糖原153(CA153),糖原242(CA242),糖原199(CA199),前列腺特异性抗原(PSA),游离前列腺特异性抗原(f-PSA),铁蛋白(FER),β-人绒毛膜促性腺激素(β-HCG),人生长激素(HGH)的水平并进行统计学分析。结果80例胃癌患者血清有74例血清肿瘤标志物为阳性(阳性率为92.75%),70例良性胃疾病中10例肿瘤标志物为阳性(阳性率为14.28%),50份正常对照血清有1例血清肿瘤标志物为阳性(特异性为98%)。试验还发现部分胃癌患者血清中出现NSE,HGH,PSA,f-PSA。结论多肿瘤蛋白芯片的应用,对胃癌患者的术前肿瘤良恶性的判定有一定的临床应用价值。Objective To investigate the application of multi-tumor markers protein chip diagnostic system in the diagnosis of gastric cancer. Methods Of the 80 patients with gastric cancer, 70 patients who suffered from benign digestive disease and 50 healthy parsons served as controls. The contents of alpha fetoprotein （AFP）, earcinoembryonic antigen （CEA）, neuron-specific enolase （NSE）, carbohydrate antigen 125 （CA125）, carbohydrate antigen 153 （CA153）, carbohydrate antigen 242 （CA242）, carbohydrate antigen 199 （CA199）, prostate specific antigen （PSA）, free prostate specific antigen （fPSA）, ferritin （FER）, β-human chorionic gonadotrophin （β-HCG） and human growth hormone （HGH） in the serum of 80 patients with gastric cancer, 70 patients with benign digestive disease and 50 healthy persons were determined with multi-tumor markers protein chip assistance diagnostic system and analyzed with statistic method. Results There were 74 patients （92.75%） with tumor makers in serum in 80 cases of gastric cancer, 10 cases （14.28%） with tumor makers in 70 cases of benign digestive disease, and 1 case with tumor makers in 50 cases of normal controls. The NSE, HGH, PSA and f-PSA were detected in the serum of partial patients with gastric cancer. Conclusion The application of multi-tumor markers protein chip diagnostic system has certain clinical value in the diagnosis of gastric cancer before surgery.

关 键 词：胃肿瘤 蛋白质阵列分析 甲胎蛋白类 癌胚抗原 磷酸丙酮酸水合酶 CA-125抗原 CA-15-3抗原 CA-19-9抗原 前列腺特异抗原 铁蛋白 生长激素 绒毛膜促性腺激素 

分 类 号：R735.2[医药卫生—肿瘤]