宁肠汤对肠易激综合征大鼠下丘脑-垂体-肾上腺轴干预作用研究  

Regulation of Ningchang decoction on hypothalamus-pitutary-aderenal gland axis(HPAA) of stressed IBS rats

作　　者：石君杰[1] 王海云[2] 邵国民 

机构地区：[1]浙江医学高等专科学校医学一系内科教研室,浙江杭州310053 [2]浙江省立同德医院儿科,浙江杭州310012 [3]浙江中医学院附属医院检验科,浙江杭州310006

出　　处：《中国中西医结合消化杂志》2006年第2期93-95,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：浙江省中医药管理局科研基金课题(2004Y009)

摘　　要：[目的]探讨宁肠汤对肠易激综合征(IBS)大鼠神经内分泌功能的调节作用。[方法]以夹尾、束缚刺激作为应激原复制IBS大鼠模型,采用放免法检测模型大鼠下丘脑-垂体-肾上腺(HPA)轴功能,观察宁肠汤的调节作用。[结果]IBS大鼠HPA轴兴奋亢进,皮质醇、促肾上腺皮质激素水平明显升高(P<0.01)。而宁肠汤能降低皮质醇、促肾上腺皮质激素的水平,抑制HPA轴的兴奋性。[结论]宁肠汤对应激引起的的神经内分泌功能紊乱有一定的调节作用。[Objective] To investigate the regulation of Ningchang decoction （ND） on neuroendocrine function of stressed IBS rats. [Methods] The stressed IBS rat model was made by chronic binding stress and nipping the tail. RIA was adopted to measure the function of hypothalamuspitutary-adrenal gland axis（HPAA） of stressed IBS rats. The regulation of ND was observed. [Results] Stress increased the contents of serum corticotropin and adrenocortictropin homone （ACTH） （P〈0. 01）, which suggested that the excitabity of HPAA was enhanced. While ND could decrease HPAA excitability of stressed IBS rats. [Conclusion]ND could regulate the disorder of neuroendocrine- function of stressed IBS rats.

关 键 词：肠易激综合征 下丘脑-垂体-肾上腺轴 宁肠汤 

分 类 号：R574[医药卫生—消化系统]