六君子加减方对胃溃疡大鼠胃黏膜愈合及胃组织6-酮-前列腺素F1α的影响  

Influence of adjusted Liujunzi formula on concrescence of gastric mucous and 6-keto-PGF1α of gastric tissue in rats

作　　者：李超波[1] 张学智[1] 梁文郁[1] 李江[2] 

机构地区：[1]北京大学第一医院中西医结合科,北京100034 [2]北京大学第一医院消化内科,北京100034

出　　处：《中国中西医结合消化杂志》2006年第2期105-107,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家中医药管理局资助项目(04-05LP14)

摘　　要：[目的]观察六君子加减方对Okabe溃疡模型大鼠胃黏膜愈合及胃组织6-酮-前列腺素F1α(6-keto-PGF1α)的影响。[方法]采用Okabe乙酸烧灼法,在大鼠胃前壁造成溃疡,随机将模型动物分为模型,六君子大、中、小剂量,硫糖铝及法莫替丁组,分别连续给药治疗10 d。给药结束后,计算各组大鼠溃疡面积和溃疡指数,测定溃疡组织胃黏膜肌层缺损宽度及再生黏膜厚度,同时定量检测溃疡周围组织6-keto-PGF1α的水平。[结果]与模型组相比,所有给药组均能够降低黏膜肌层缺损宽度,提高再生黏膜厚度、胃组织6-keto-PGF1α的水平(均P<0.01);以六君子大剂量组作用更明显,与两西药组相比,差异有统计学意义(P<0.05)。[结论]六君子加减方能减小溃疡面积和溃疡指数,降低黏膜肌层缺损宽度,提高再生黏膜厚度,提高大鼠胃组织6-keto-PGF1α,提高溃疡大鼠胃黏膜愈合程度。[Objective]To observe the effect of adjusted Liujunzi formula （ALF） on concrescence of gastric mucous and 6-keto-PGF1α of gastric tissue in rats and illustrate its mechanism of protecting the gastric mucous. [Methods] The gastric ulcer model was established with Okabe＇s method （dropping acetic acid on gastric surface）. Rats＇ models were randomly divided into 6 groups which were given respective medicine for 10 days： the model group, the high, moderate and low dosage ALF group and the sucralfate group and famotidine group, respective. Then the area and index of ulcer, the absent width of gastric mucous and the thickness of regenerated mucous and the level of 6-keto-PGF1α in gastric tissue were measured. [Results] The thickness of regenerated mucosa and the level of 6-keto-PGF1α in gastric mucous of the model group was lower, while the area and index of ulcer and the absent width of gastric mucous was higher than that of other groups respectively （P〈0.01）. The effect of the high dosage ALF group was obvious, which was statistically better than that of west medicine groups. （P〈0. 05） [Conelusion]ALF could decrease the area and index of ulcer, reduce the absent width of gastric mucous, increase the thickness of regenerated mucous and level of 6-keto-PGF1α, and improve the degree of concrescence.

关 键 词：胃溃疡 六君子加减方 6-酮-前列腺素F1Α 

分 类 号：R573.1[医药卫生—消化系统] R289.5[医药卫生—内科学]