血友病A患者丙肝感染现状的调查  

Investigation of hepatitis C virus epidemiology infection in patients with hemophilia A of Wenzhou city

作　　者：黄瑛[1] 朱淼勇[1] 金小丽[2] 夏淑琦[2] 胡理明[1] 陈萍[1] 谢炳寿[1] 

机构地区：[1]浙江省温州市第三人民医院血液科,温州325000 [2]浙江省温州市第三人民医院检验科,温州325000

出　　处：《江西医药》2006年第3期127-129,共3页Jiangxi Medical Journal

摘　　要：目的了解血友病A患者血液传播性丙型肝炎病毒(HCV)的感染现状。方法对经本院确诊的56例血友病A患者进行了ALT、抗-HCV检测,并与2004年本院输血、手术前检测结果(对照组)共8429例做对比分析。结果56例血友病A患者的ALT、抗-HCV阳性率分别为19.64%、35.71%,对照组ALT、抗-HCV阳性率分别为3.44%、0.61%,血友病A患者的ALT、抗-HCV阳性率均显著高于对照组(P值均<0.0005)。结论血友病A患者是HCV感染的高危人群,且HCV感染是血友病A患者肝功能受损的主要因素,1995年以后诊断的血友病A患者丙肝的发生率显著下降。Objective To understand the infection with hepatitis C virus（HCV） in patients with hemophilia A of Wenzhou city. Methods ALT, anti-HCV in patients with hemophilia A were analyzed. 8429 patients who need transfusion or surgery therapy in the hospital in 2004 was taken as control group. Results In 56 hemophilic patients investigated, the positive rates of ALT and anti-HCV were 19.64%and 35.71% respectively. The results revealed that the positive rates of ALT and anti-HCV in hemophilic patients were higher than that in control group （P〈0.0005）. Conclusion HCV is popular in the patients with hemophilia A, and it plays a major role in abnormal liver function in hemophiliacs. Hepatitis C virus（HCV） is significantly reduced in hemophiliacs diagnosed after 1995.

关 键 词：血友病A 丙氨酸氨基转移酶(ALT) 丙型肝炎病毒 

分 类 号：R554.106[医药卫生—血液循环系统疾病]