超选择动脉插管灌注化疗与栓塞治疗中晚期胃癌  

Ultra-selective Arterial Infusion Chemotherapy and Chemoembolization in Treatment for Advanced Gastric Cancer

作　　者：李茂江 徐艳 

机构地区：[1]青岛市胶州中心医院,山东青岛266300

出　　处：《肿瘤学杂志》2006年第2期143-144,共2页Journal of Chinese Oncology

摘　　要：[目的]探讨超选择动脉插管灌注化疗与栓塞治疗中晚期胃癌的临床疗效。[方法]对36例不能手术切除及6例术后复发的中晚期胃癌患者行超选择性动脉插管灌注化疗与栓塞治疗。治疗方案为FAM(5-氟尿嘧啶、阿霉素或表阿霉素、丝裂霉素)或FPM(5-氟尿嘧啶、顺铂或卡铂、丝裂霉素),栓塞剂为超液化碘油。[结果]每例进行2～3次插管,共108人次。完全缓解3例,部分缓解35例,无变化4例,无PD病例,显效率90.5%。1、2、3年生存率分别为61.9%(26/42)、19.0%(8/42)、9.5%(4/42)。[结论]超选择动脉插管灌注化疗与栓塞治疗中晚期胃癌是一种安全有效的治疗方法,不仅能增加疗效,而且能改善生存质量,提高生存率。[Purpose] To explore the efficacy of ultra-selective arterial infusion chemotherapy and ehemoembolization in treatment for advanced gastric cancer. [Methods] Forty-two eases with advanced gastric cancer including unreseetable 36 cases and local recurrent eases underwent ultraselective arterial infusion chemotherapy and chemoembolization. Chemotherapy was carried out with FAM regimen（5-fluorouraeil,mitomyein and adriamycir, or epirubicin） or FPM regimen（5-fluorouraeil, mitomycin and eisplatin or carboplatin）. Ultra-fluid lipiodol was used for embolization. [ Results ]Two to three times catheterizations were perfermed in each case,with a total of 108 times. Complete response（CR） was found in 3 cases;partial response（PR）,35 cases; no change, 4 cases. No disease progressive cases was foL, nd.Overall response rate was 90.5%,and the 1-,2-,3-year survival r.＇,te was 61.9%（26/42）, 19,0%（8/42）,9.5%（4/42）respectively. [ Conclusion ] The ultra-selective arterial infusion chemotherapy and chemoemholizatim, are effective methods in the treatment for advanced gastric cancer. They can not only enhance the efficacy, but also improve patients＇ quality of life and survival.

关 键 词：胃肿瘤 动脉 灌注 局部 化学栓塞 治疗性 

分 类 号：R735.2[医药卫生—肿瘤]