上海市南汇区“筛检-干预”卒中预防策略潜在利益分析  

A“Screen-Intervention" Strategy for Primary Prevention of Stroke in Nanhui County of Shanghai City: Potential Benefit

作　　者：王桂清[1] 黄久仪[1] 曹奕丰[1] 沈凤英[1] 王艳[1] 郭吉平[1] 俞学海[1] 杨永举[1] 张旭静[1] 陈海艳[1] 

机构地区：[1]上海市脑血管病防治研究所

出　　处：《中西医结合心脑血管病杂志》2006年第4期284-286,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市政府专项基金项目(沪科合99第005号)

摘　　要：目的分析和评价上海市南汇区“筛检-干预”卒中一级预防策略实施3年的潜在利益。方法在全区69.7万框架人群中选择≥35岁具有卒中危险因素暴露的人群进行脑血管血流动力学指标(CVHI)检测,筛选出18271人CVHI积分值<70分的卒中高危个体,根据知情同意原则分成药物干预组(10313人)和对照组(7958人),实施3年干预和随访卒中发病。计算每预防1例卒中需要筛检的人数(NNS)和需要治疗的人数(NNT)。结果针对筛检出的高危个体实施全部干预方案的NNS为148,根据知情同意原则实施部分干预方案的NNS为268。干预策略实施3年的NNT为51。结论“筛检-干预”卒中一级预防策略实施3年后可取得良好的效益。Objective To analyze and evaluate potential benefit of 3 years intervention by ＂screen- intervention＂ primary prevention strategy of stroke in Nanhui county of Shanghai city. Methods Sixty - seven thousand individuals aged ≥35 years with at least one risk factor were screened from 697 thousand populations, who were carried out cerebrovascular hemodymanic indexes （CVHI） examination. The candidates of 18 271, whose CVHI accumulative score under 70 points were defined as high risk individual and divided into pharmaceutical group （n =10 313 cases） and control group （ n =7 958 cases） according to willing of them self. Intervention was carried out for 3 years and incidence of stroke was followed up. Both number need to screen （NNS） and number need to treat （NNT） were estimated in the trial. Results NNS for 3 years in overall intervention strategy was 148 and in partial intervention strategy was 268. NNT for 3 years intervention was 51. Conclusion The result suggested that there was reasonable benefit after 3 years intervention of ＂screen - intervention＂ primary stroke prevention strategy.

关 键 词：卒中 筛检 干预试验 

分 类 号：R743.3[医药卫生—神经病学与精神病学]