辽宁地区入院女性乳腺癌遗传度及相关危险因素的条件Logistic回归分析  

Breast cancer genetic epidemiology study and conditional logistic regression analysis of relative risk factors of female in hospital in liaoning province

作　　者：李霓[1] 何苗[1] 张曦[2] 李雪莲[1] 吴伟[1] 李鸣川[1] 周宝森[1] 

机构地区：[1]中国医科大学流行病教研室,辽宁沈阳110001 [2]沈阳市卫生监督所,辽宁沈阳110001

出　　处：《中华肿瘤防治杂志》2006年第2期101-106,共6页Chinese Journal of Cancer Prevention and Treatment

基　　金：中华医学基金会资助项目(cmb00726)

摘　　要：目的:探讨辽宁地区女性乳腺癌的家族聚集性,并对其危险因素进行分析。方法:采用按年龄进行1∶1配比的病例对照研究方法,对620例乳腺癌患者及其对照采用LiMantelGart法进行乳腺癌分离比的估算;Falconer回归法进行遗传度估算;条件Logistic回归进行其危险因素分析。结果:乳腺癌的分离比为0.11±0.011。先证家系中一级亲属的遗传度为(45.90±3.869)%,二级亲属遗传度为(14.31±12.68)%。单因素条件Logistic回归结果显示:有乳腺癌家族史,有其他癌症家族史,体质指数(bodymassindex,BMI)>24,月经周期不规律,流产次数较多,未曾哺乳,有过较大精神刺激,受教育程度较高以及用染发剂等化学品为乳腺癌的危险因素(P<0.05);多因素条件Logistic回归结果表明,乳腺癌家族史,其他癌症家族史,BMI>24,月经周期不规律,流产次数多,未曾哺乳,教育程度高,和使用染发剂等化学物品(P<0.05)为乳腺癌的危险因素。结论:辽宁地区女性乳腺癌发生是多因素综合作用的结果,其中遗传因素起重要作用,其他的危险因素为BMI>24,月经周期不规律、流产次数多、未曾哺乳、教育程度高以及用染发剂等化学品。OBJECTIVE：To evaluate the contribution of the genetic factor to the occurrence of female breast cancer in Northeast China and analyze the relative risk factors. METHODS： A case-control study was conducted on 620 cases of breast cancer with histopathological diagnosis and 620 matched controls, by using the method of Li-Mantel-Gart and Falconer to estimate the segregation ration and heritability. Conditional Logistic regression model, stratification analysis and interaction analysis were used to analyze the relative risk factor. RESULTS.. Segregation ration of female breast was 0. 11±0. 011. The heritability of the first and second degree relatives were （45. 90±3. 869）% and （14. 31±12.68）% respectively. Nine factors （family history of breast cancer, family history of the other cancers, BMI 〉 24, menstrual disorder, abortion times〉 2, non-lactation, psychological trauma, high level education and using hair dye） were associated with female breast cancer in univariate conditional Logistic regression model. Multivariate conditional Logistic regression analysis in total significant factors showed that the risk factors of female breast cancer included family history of breast cancer, family history of the other cancers, BMI〉24, menstrual disorder, abortion times〉2, non-lactation, high level education and using hair dye. CONCLUSIONS： The occurrence of female breast cancer in Northeast area of China results from multiple factors. Genetic factor plays important role. The other risk factors are family history of breast cancer, family history of the other cancers, BMI〉24, menstrual disorder, abortion timea〉2, non-lactation, high level education and using hair dye.

关 键 词：乳腺肿瘤/遗传学 危险因素 病例对照研究 回归分析 

分 类 号：R737.9[医药卫生—肿瘤]