鼻咽癌组织中Survivin的表达与预后关系  

Expression of survivin in nasopharyngeal carcinoma and its prognostic significance

作　　者：向燕群[1] 姚和瑞[2] 郭翔[1] 洪明晃[1] 曹素梅[1] 闵华庆[1] 

机构地区：[1]中山大学肿瘤防治中心鼻咽癌科,广东广州510060 [2]中山大学附属第二医院肿瘤科,广东广州510120

出　　处：《中华肿瘤防治杂志》2006年第2期120-123,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：广东省社会发展领域科技计划项目(粤科社[2003]245号)

摘　　要：目的:检测IAP家族蛋白Survivin在鼻咽低分化鳞癌组织中的表达情况及其与鼻咽癌患者的临床特征及预后的关系。方法:免疫组化LSAB法检测92例初治无远处转移的鼻咽低分化鳞癌患者鼻咽肿瘤组织中Survivin的表达情况,分析其表达与各项临床指标的关系。KaplanMeier法分别分析Survivin的表达与鼻咽癌根治性放疗后总生存率的关系。用Cox风险比例模型进一步分析各预后指标与鼻咽癌患者总生存率的关系。结果:Survivin在鼻咽癌组织中表达的百分数平均为(37.24±30.94)%。以癌细胞表达(++)以上(即>25%)为高表达的判断标准,则高表达率分别为56.52%(52/92)。在不同性别、年龄、鼻咽原发灶的侵犯范围、临床分期和有无局部复发、有无远处转移的病例中,鼻咽癌组织Survivin的表达情况差异无统计学意义,P>0.05;但是Survivin的高表达与有无颈部淋巴结转移有关,有颈部淋巴结转移的患者肿瘤组织Survivin高表达的比例增加,P<0.05。生存分析显示,Survivin低表达组和高表达组的患者5年累积总生存率分别为87.21%和52.28%(P=0.004);进一步的多因素Cox回归模型分析结果显示T分期和Survivin高表达与总生存率有关。结论:部分鼻咽癌组织中存在Survivin的高表达。其中Survivin的高表达与鼻咽癌患者颈部淋巴结转移及生存期的缩短有关。Survivin可作为鼻咽癌的预后指标。OBJECTIVE：To evaluate the expression of survivin in nasopharyngeal carcinoma （NPC） and the relationship between the expression and the clinical characteristics and its prognostic value. METHODS： Expression of survivin was investigated by using the immunohistochemical staining method in 92 cases of NPC. Life table, Kaplan-Meier analysis and Cox regression analysis were used in discussing the prognosis. RESULTS： The average positive rates of survivin in NPC was （37.24±30. 94）%. Tumors were scored high expression level when 〉25% cancer cells stained positive, thus the high expression of survivin was 56.52% （52/92）. There were no significant correlations between survivin and age, sex, primary tumor size, localregional relapse and distant metastasis, but high lymphnode metastasis rate was seen in the high expression group of survivin. When analyzed for prognostic significance, patients with low survivin expression had better overall survival than the group with high survivin expression （87.21% vs 52.28%, P=0. 004）. Cox regression analysis confirmed that high survivin expression was related to worse prognostic in NPC patients. CONCLUSIONS： There is high expression level of survivin in NPC, which may play an important role in the oncogenesis and tumor development. Over expression of survivin is related to poor prognosis of NPC patients. The determination of survivin expression may provide predictive information on NPC patients.

关 键 词：鼻咽肿瘤/病理学 基因表达 免疫组织化学 预后 

分 类 号：R739.63[医药卫生—肿瘤]