益生菌治疗亚临床肝性脑病对其转归的影响及机制  

Effects of probiotics agents treatment on the couse of subclincal hepatic encephalopathy

作　　者：刘建生[1] 田怡[1] 付极[1] 张晓红[1] 刘进[1] 林健[2] 

机构地区：[1]上海瑞金医院集团闵行医院消化科,201100 [2]上海交通大学医学院

出　　处：《中国医师进修杂志》2006年第1期12-14,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨益生菌(复合乳酸菌胶囊,聚克)治疗亚临床肝性脑病(SHE)对其转归的影响及机制。方法随机将60例经数字连接试验(NCT)、数字符号试验(DST)和/或体感诱发电位(SEP)检查异常的SHE患者分配入治疗组、对照组各30例。治疗组给予聚克和复合维生素B治疗8周,对照组仅给予复合维生素B治疗8周。两组均在第4、8周末随访,作血氨、肝功能、SEP、NCT、DST,并观察肝性脑病(HE)的发病率。结果治疗后4周两组间比较在肝功能、血氨、SEP各波潜伏期差异均无统计学意义(P>0.05),但在NCT、DST、HE发病率差异均有统计学意义(P<0.05);第8周治疗组血氨较对照组有改善(P<0.05)。结论益生菌治疗能降低血氨,改善智力测验和降低HE发病率。Objective To study the effects of probiotics agents treatment on the course of subclincal hepatic encephalopathy （SHE）. Methods Sixty SHE patients with abnormal were randomly divided into two groups：treatment group（30 cases） was treated with polylactone and vitamin B complex for 8 weeks. Control group （30 cases） was treated with vitamin B complex only for 8 weeks. Blood ammonia, liver funtion, number connection test （NCT）, digital symbol test （D,ST）, and somatosensory evoked potential（SEP） were investigated 4,8 weeks after the onset of experiment. The incidence of HE was recorded. Results No statiseally significant difference was found in terms of liver function and SEP any time after the onset of the experiment（all P 〉 0.05）. However, significant difference in NCT and DST performance, incidence of HE the 4th week after （ P 〈 0.05）. Since the 8th week, there was significant difference in blood ammonia （P 〈 0.05）. Conclusion Probiotics agents treatment can decrease ammonia and improve the psychmetric performance and the prevalence of clinical HE.

关 键 词：肝性脑病 益生菌 治疗 

分 类 号：R747.9[医药卫生—神经病学与精神病学] R735[医药卫生—临床医学]