尿激酶溶栓治疗急性脑梗死患者血浆NO、ET和D-二聚体含量变化及临床意义  

Content change and clinic significance of NO,ET,D-Dimer with UK in the treatment of ACI

作　　者：韦继政[1] 吕小亮[2] 李素珍[1] 

机构地区：[1]暨南大学医学院第六附属医院,江门529031 [2]暨南大学医学院第六附属医院恩平分院

出　　处：《中国医师进修杂志》2006年第2期11-13,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨急性脑梗死患者尿激酶溶栓治疗前后血浆一氧化氮(NO)、内皮素(ET)和D-二聚体含量动态变化及临床意义。方法测定38例急性脑梗死患者溶栓前及溶栓后2 h、4 h2、4 h4、8 h血标本NO、ET和D-二聚体含量,并与正常对照组33例进行比较。结果脑梗死患者NO含量明显低于正常对照组(P<0.01),血浆ET和D-二聚体含量显著高于对照组(P<0.01和P<0.05)。溶栓后有效组24 h后NO明显升高,与溶栓前差异有统计学意义,而无效组无显著变化。有效组4 h后ET明显下降,以后降幅较小,但明显低于无效组。结论血浆NO、ET和D-二聚体含量可以作为急性脑梗死的诊断指标,溶栓治疗后NO、ET与D-二聚体水平变化对判断疗效有一定指导意义。Objective To study the content change and clinic significance of NO, ET, D- Dimer with UK in the treatment of ACI. Method NO, ET, and D - Dimer were measured before and after 2 h, 4 h, 24 h, 48 h in 38 ACI patients with treatment of UK by the ways NO- 2/NO- 3 content measuring, radiation immunity analysis（RIA） and ELISA. Results NO in ACI was significantly low （P〈0.01）, and ET（P〈0.01） and D- Dimer were significantly high（P〈0.05） in the treatment group comparing with the mntrol group. There was negative mutuality during NO and ET, D - Dimer（r = - 0.64, P 〈 0.05）, positive mutuality within ET and D - Dimer （ r = ＋ 0.52, P 〈 0.05）. NO was higher when treating ACI patients with UK after 24 h, and there was a significant difference in effected group and was not in inefficacy group. ET in effected group was lower than inefficacy group and descend distinctly after 4 h, then it desoended slowly. Conclusion NO, ET and D Dimer can be used markers to diagnose ACI and to guide the treatment of dissolving thrombosis with UK in ACI.

关 键 词：脑梗死 内皮素 一氧化氮 D-二聚体 尿激酶 

分 类 号：R743.33[医药卫生—神经病学与精神病学]