丝裂霉素纳米微粒-碘油乳剂经动脉给药对兔肝肿瘤的疗效观察  

Therapeutic effects of mitomycin-loaded nanoparticles-lipiodol administered via hepatic artery against rabbit hepatoma

作　　者：易军[1] 陈江浩[1] 凌瑞[1] 王岭[1] 贠军[1] 姚青[1] 李南林[1] 李哓军[1] 

机构地区：[1]第四军医大学西京医院普通外科,陕西西安710032

出　　处：《中华肿瘤防治杂志》2006年第4期263-265,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：陕西省自然科学基金项目资助(2001SM37)

摘　　要：目的:观察丝裂霉素纳米微粒-碘油乳剂经动脉给药对兔肝肿瘤的疗效。方法:将丝裂霉素纳米微粒与碘油制成乳剂,建立兔肝VX-2移植癌改良模型并随机分为六组,经肝动脉分别注入生理盐水(NS)、碘油(Lipi)、游离丝裂霉素(MMC,0·4mg/kg)、游离丝裂霉素加空白纳米微粒(MMC+NP,0·4mg/kg)、丝裂霉素纳米微粒组(NMMC,0·4mg/kg)与丝裂霉素纳米微粒-碘油乳剂(Lip-NMMC,0·4mg/kg)。结果:经Lip-NMMC治疗的兔生存期显著延长,P<0·01;与其他各组相比对肿瘤生长的抑制更为明显,P<0·01;肿瘤坏死更广泛,更彻底。结论:与其他各组相比,Lip-NMMC经动脉给药具有更好的疗效。OBJECTIVE： To evalunte the therapeutic effects against rabbit hepatoma with mitomycin-loaded nanoparticles-lipiodol （Lip-NMMC） administered via hepatic artery. METHODS： Lip- NMMC was prepared by the interfacial polymerization method. Norreal saline, lipiodol, free mitomycin （MMC, 0. 4 mg/kg）, mitomycin plus blank nanoparticle （MMC＋NP, 0. 4 mg/kg）, mitomycin-loaded nanoparticles （NMMC, 0. 4 mg/kg）, and Lip-NMMC were injected respectively via the hepatic artery into six groups of rabbit VX-2 liver tumor models. RESULTS：The survival time was prolonged significantly in animals treated with Lip-NMMC, P〈0. 01. The tumor growth inhibition was more significant, P〈0. 01 and necrosis more extensive in comparison with animals received the others. CONCLUSION： Hepatic arterial infusion of Lip-NMMC is more effective compared with other prepartions.

关 键 词：肝肿瘤 实验性/药物疗法 丝裂霉素类/投药和剂量 纳米技术 模型 动物 

分 类 号：R735.7[医药卫生—肿瘤]