选择性动脉插管同步放化疗治疗中晚期鼻咽癌的临床研究  

Clinical study of selected concurrent arterial chemotherapy and radiotherapy on intermediate and advanced nasopharyngeal carcinoma

作　　者：李庆[1] 赵新华[2] 周定中[1] 

机构地区：[1]湘南学院附属医院放射科,湖南郴州423000 [2]郴州市第三人民医院肿瘤科,湖南郴州423000

出　　处：《中华肿瘤防治杂志》2006年第6期462-464,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：湖南省卫生厅课题(B2003-150)

摘　　要：目的:研究选择性动脉插管同步放化疗治疗中晚期鼻咽癌的价值。方法:采用前瞻性随机对照研究,将50例中晚期初治鼻咽癌患者于治疗前用抽签法随机分成两组,25例进行选择性动脉插管同步放化疗(治疗组),25例采用全身静脉化疗联合放疗组(对照组)。两组放疗方法、时间和剂量分割均相同。结果:放疗结束4周评定疗效,治疗组与对照组总缓解率分别为96%(24/25)和68%(17/25),治疗组的凋亡指数和细胞增殖指数数据均高于对照组,两组比较差异有统计学意义,P<0·05。结论:选择性动脉插管同步放化疗治疗中晚期鼻咽癌近期疗效显著,毒副反应轻,是一种安全、有效的治疗方法。OBJECTIVE： To study the selected concurrent arterial cheraotherapy and radiotherapy on intermediate and advanced nasopharyngeal carcinoma （NPC）. METHODS： Fifty patients with intermediate and advanced NPC confirmed by pathology were randomly divided into two groups before radiotheray, and the two groups were given two different methods of treatment., selected concurrent arterial chemothempy and radiotherapy or combined general intravenous chemotherapy and radiotherapy. RESULTS.. At four weeks following completion of radiotherapy, the total response rates in the two groups were 96%（24/25） and 68%（17/25） respectively, and Apoptosis Index（AI） and PCNA（PI） of the treatment group were higher compared with the group of patients receiving radiotherapy. The difference of two group was significant, P〈0. 05. ODNCLUSION： Sleeted concurrent arterial chemotherapy and radiotherapy is a safe and effective treatment for patients with intermediates and advanced NPC.

关 键 词：鼻咽肿瘤/放射疗法 鼻咽肿瘤/药物疗法 综合疗法 

分 类 号：R739.63[医药卫生—肿瘤]