头颈部肌上皮癌8例报告  

Myoepithelial Carcinoma of Head and Neck (a report of 8 cases)

作　　者：冯锦标[1] 陈良嗣[2] 梁健刚[1] 张思毅[2] 蒙翠原[2] 宋新汉[2] 庄恒国[3] 

机构地区：[1]广州市番禺区人民医院耳鼻咽喉科,511400 [2]广东省人民医院耳鼻咽喉-头颈外科 [3]广东省人民医院病理科

出　　处：《肿瘤防治研究》2006年第4期277-279,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨头颈部肌上皮癌的生物学行为、诊断、治疗及预后。方法回顾性分析8例头颈部肌上皮癌临床资料,并复习文献。结果8例中原发于腮腺3例,颌下腺2例,硬腭1例,鼻腔鼻窦2例。经病理组织学和免疫组织化学确诊。8例均行根治性手术治疗,4例术后局部复发,6例出现远处转移,分别在术后8个月至5年内死亡。5例死于远处转移,3例死于恶液质。结论头颈部肌上皮癌较为罕见,肿瘤生物学行为具有生长迅速、颈部淋巴结转移率高、血行转移率高、治疗后易复发、预后差等特点。该瘤缺乏特征性临床表现,诊断依赖病理和免疫组化。治疗以根治性手术为主,术后可辅以化、放疗。Objective To discuss the biological behavior, diagnosis, treatment, and prognosis of myoepithelial carcinoma in head and neck. Methods Records of 8 patients with myoepithelial carcinoma in head and neck were retrospectively analyzed, at the same time the literatures were reviewed. Results There are 3 cases in parotid gland, 2 cases in submaxillary salivary gland, 1 case in hard palate, 2 cases in nasal cavity and nasal sinus. All cases were exactly diagnosed by pathohistology and immunohistochemistry. All cases were radically operated. After operation, 4 cases occurred local recurrence and 6 cases occurred distant metabasis. 5 cases died from distant metastasis and 3 cases died from dyscrasia after operation within 5 years. Conclusion Myoepithelial carcinoma is rarer tumor. According to the 8 cases and literatures, the characteristics of the tumor are rapidly enlarging, extensively invading the surrounding tissues, high rate of lymph node metastasis, high rate of distant metastasis, very frequent recurrence after surgical excision, and poor prognosis. There aren＇t classical clinical features for patients with myoepithe lial carcinoma in head and neck. Diagnosis is depended on histology and irnmunohistochemistry. A radical operation must be implementing at first. Chemotherapy and radiotherapy are beneficial adjunctive therapy after operation.

关 键 词：头颈部肿瘤 肌上皮癌 生存率 

分 类 号：R739.87[医药卫生—肿瘤]