基于快速生长期大鼠在不同应力环境中活骨实验的骨适应生物模型数字量化研究  

Quantification Study of Bone Adaptive Model Based on Experiment of Rapid-growing Rats in Different Stress Environment

作　　者：刘迎曦[1] 张军[1] 赵文志[1] 孙秀珍[2] 孙晓江[3] 

机构地区：[1]大连理工大学工程力学系工业装备结构分析国家重点实验室,大连116024 [2]大连医科大学第二临床学院耳鼻咽喉头颈外科,大连116025 [3]大连医科大学第二临床学院骨科,大连116025

出　　处：《生物医学工程学杂志》2006年第2期318-321,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10472025);辽宁省自然科学基金资助项目(20032109)

摘　　要：本研究提出了将动物实验、数学表达式的未知参数识别和计算机仿真技术相结合的方法建立数值量化的骨生长与重建自适应生物模型。通过设计一种新的动物实验,研究不同应力环境对快速生长期大鼠股骨生长与重建的影响,依据等时间间隔提取的大鼠股骨骨密度数值,反演了骨生长方程中的未知生物参数B和K,根据股骨的CT截面信息,重塑了三维几何模型。文中提出的这种模型及建模方法不仅能够量化表示骨密度变化量和外界刺激值之间的关系,而且能够预测大鼠整个生命周期内不同应力环境中骨的生长情况。本文的建模思路和研究方法对于人体骨骼生长重建适应模型的建立也会有一定的借鉴意义。Presented is a method to set up a quantification model of bone growing and remodeling adaptation, which integrates animal experiments, parameter identification of mathematical functions and technique of computer simulation. By designing a new animal experiment, we investigate the effects of growing and remodeling of the rat femurs in different stress environments, gather the bone mineral density （BMD） of proximal femur in the same interval for the unknown parameter （B and K） inversion of bone growing and remodeling equation and create the femur three-dimensional geometrical model based on CT images. The model in this paper can not only numerically measure the relation between outer stimulus and the femur BMD variation of rapid growing rats, but also predict the growth trend of rat femur under different stress environments in its whole lifecycle. The thought and method of creating the model in this paper can be used for reference to modeling human bone growth and remodeling.

关 键 词：骨 自适应模型 动物实验 反演理论 三维重建 

分 类 号：R318.01[医药卫生—生物医学工程]