基底神经节的书写功能  

The writing function of the basal ganglia

作　　者：刘晓加[1] 金梅[1] 吴湖炳[2] 陆兵勋[1] 尹文刚[3] 

机构地区：[1]南方医科大学南方医院神经内科,广州510515 [2]南方医科大学南方医院PET中心,广州510515 [3]中国科学院心理研究所

出　　处：《中国行为医学科学》2006年第4期294-296,共3页Chinese Journal of Behavioral Medical Science

基　　金：国家自然科学基金(30370486)

摘　　要：目的通过葡萄糖代谢率比值的测定评价基底神经节在汉语书写中的作用,探讨其神经心理学机制。方法10名大学本科一年级学生,以正电子发射计算机断层显像为检测手段,观察和比较受试者在假写状态及文字书写状态下基底神经节的葡萄糖代谢情况。结果10名受试者在文字书写状态较假写状态,左侧豆状核差值(0.0435±0.0396),右侧豆状核差值(0.0634±0.0301),左侧尾状核差值(0.0463±0.0384),右侧尾状核差值(0.0566±0.0396),差异具有显著性(均P<0.05);双侧豆状核、尾状核的激活值差异无显著性(均P>0.05)。结论双侧基底神经节均参与了汉语文字书写的过程。Objective To evaluate its role in Chinese writing and investigate its neuropsychological mechanism by measuring the ratio of glucose metabolism on the basal ganglia. Methods 10 cases of healthy subjects, freshmen of undergraduate, aged from 18 to 24, were studied with positron emission tomography using ^18F-2-fluoro- 2-deoxy-D-glucose as tracer to observe and compare the glucose metabolism of basal ganglia during pseudo-writing and characters writing. Results During the process of characters writing in contrast to that of pseudo-writing in 10 subjects, a significant activation（ P〈 0.05 ）was showed in the left lentiform nucleus （0. 0435 ± 0. 0396）, the right lentiform nucleus （0. 0634 ±0.0301）, the left caudate nucleus （0.0463 ± 0.0384）, the right caudate nucleus （0. 0566 ±0. 0396）. There is no significant difference between the two sides in the activation of the lentiform nucleus and caudate nucleus （ P 〉 0. 05 ）. Conclusion The bilateral basal ganglia participates in the process of characters writing.

关 键 词：书写 基底神经节 正电子发射计算机断层显像 

分 类 号：R741[医药卫生—神经病学与精神病学]