精神分裂症患者半球机能不对称性分听研究  

Lateralized hemisphere function in dichotic listening in schizophrenic patients

作　　者：初建峰[1] 姜存国 王毅[3] 

机构地区：[1]济宁市第一人民医院神经内科,济宁272111 [2]兖州矿务局北宿矿医院 [3]昆明医学院第一附属医院神经内科

出　　处：《中国行为医学科学》2006年第4期342-343,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的比较精神分裂症患者及其不同亚型与健康者之间的耳优势关系,探讨言语加工的脑优势在不同组间的差异。方法用集中注意法及两种押韵词,对58名健康被试、62名偏执型精神分裂症患者、49名未定型精神分裂症患者进行分听研究。结果健康组真词测听[(-0.01±0.34)分]未见明显耳优势(P=0.847),而假词测听[(0.40±1.41)分]呈现出右耳优势(P=0.035);分裂症组(偏执型组与未定型组之和)在真词测试中右耳优势强于健康组,差异存在显著性(P=0.028);两组在假词测试中右耳优势差异无显著性(P=0.34);按亚型分组后,偏执型组在真词[(1.34±3.97)分]、假词[(2.33±5.54)分]测听上均较健康组有较强的右耳优势(P=0.022,0.034),未定型组真假词测听差异无显著性(P=0.149,0.887)。结论健康中国人汉字词的加工与认知,对不同的分听材料表现不同的侧化模式,对真词的加工与认知无耳优势;对假词的加工与认知则表现出右耳优势;精神分裂症患者对汉语字词的加工与认知,表现出较健康人强的右耳(左半球)优势。Objective To compare the hemispheric dominance for language characters among schizophrenic patients, various subtypes and healthy controls, and to investigate whether there are differences among different groups. Methods The ear advantage of 58 healthy subjects, 62 patients with paranoid schizophrenia, 49 patients with undifferentiated schizophrenia were examined using two kinds of rhyming words by the method of focused attention. Results In health group, no ear advantage was found in true words test （ P= 0. 847）, but signif icant right ear advantage appeared in pseudo-word test （ P = 0.035 ）. Schizophrenia group appeared larger fight ear advantage than health suhjects in true words test（ P=0. 028） ,but not in the pseudo-word （P=0.34）. After subtypes were separated, the paranoid schizophrenia group appered larger fight ear advantage than health group in both true words and pseudo-word test （ P=0. 022,0. 034）, but not in the undifferentiated schizophrenia group （ P = 0. 149,0.887）. Conclusion Health chinese appeared fight ear advantage in the pseudo-word test while there was no ear advantage for process and cognition of true words. Patients with schizophrenia have a larger right ear （left hemisphere） advantage for chinese words processing than health subjects.

关 键 词：精神分裂症 分听 脑功能偏侧化 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R338.3[医药卫生—临床医学]