重症肌无力患者血清抗心肌抗体测定的意义  

Valuation of heart muscle antibodies in the sera of patients with myasthenia gravis.

作　　者：万顺伦[1] 丛志强[2] 韩仲岩[2] 曹永献[3] 于秀英[3] 

机构地区：[1]济南军区青岛第一疗养院,266071 [2]青岛医学院附属医院神经内科 [3]青岛医学院附属医院检验科

出　　处：《临床神经病学杂志》1996年第1期15-17,共3页Journal of Clinical Neurology

摘　　要：应用免疫荧光技术,测定重症肌无力(MG)患者,健康者及其他疾病患者血清抗心肌抗体。发现23例伴胸腺瘤 MG 患者的抗心肌抗体阳性率为91.3%,而54例不伴胸腺瘤 MG 患者的阳性率仅为18.5%,健康及疾病对照组内无1例阳性。还发现伴心电图异常的 MG 患者抗心肌抗体阳性率为76.5%,而不伴心电图异常者阳性率仅为30%。结果表明抗心肌抗体的出现与 MG 伴胸腺瘤密切相关,且它与心电图异常之间也有一定的关系。此项测定可对 MG 是否合并胸腺瘤起初步筛选作用,还可作为间接估计心脏功能损害的血清学指标。By using immun of luorescence(IF),heart muscle antibodies were measured in sera from 77 MG patients and 96 controls.Heart muscle antibodies were detected in 91. 3%(21/23)MG patients with thymoma and in 18.5%(10/54)MG patients without thy- moma.Among the controls,none had heart muscle antibodies.MG may involve heart in some patients,especially in those with a thymoma.In present studies,17 of 77 MG patients had abnormal ECGs.The positive rate of heart muscle antibodies was 76.5%(13/17)in the MG patients with abnormal ECGs and 30%(18/60)in the others.These results show that the abnormal ECGs of MG patients may be present when the heart muscle antibodies appear in the sera.So,detecting the heart muscle antibodies may offer a means of serologically e- valuating the cardiac status of the MG patients and a parameter to determine whether the MG patients have thymoma or not.

关 键 词：重症肌无力 抗心肌抗体 胸腺瘤 心电图异常 

分 类 号：R746.102[医药卫生—神经病学与精神病学]