6β,19-环氧-4-雄甾烯-3,17-二酮的NMR研究  

NMR STUDIES OF 6β, 19-EPOXY-4-ANDROSTENE-3,17-DIONE

作　　者：张志亮[1] 王志强[1] 凌仰之[1] 

机构地区：[1]北京医科大学药学院

出　　处：《北京医科大学学报》1990年第2期140-142,共3页Journal of Peking University(Health Sciences)

摘　　要：通过~1H、^(13)C-NMR,采用NOE照射,同核二维偶合相关谱(COSY),异核二维化学位移相关谱(HETCOR)及APT技术确定了标题化合物的构型及所有^(13)C谱及~1H谱的归属。When the 6 β-Br or Cl steroid compounds (1a, 1b) were treated in CH_3OH/HCl, an unexpectedproduct 6 β, 19-epoxy-4-androstene-3, 17-dione (2) was obtained. It's structure was unambiguouslydetermined, by ~1H, ^(13)C-NMR, accompanied with NOE, COSY, HETCOR and APT techniques. And allof the ~1H-and ^(13)C-NMR peaks of (2) were also assigned.

关 键 词：环氧甾体 核磁共振谱 

分 类 号：TQ460.72[医药卫生—药物分析学]