饮酒与消化道肿瘤死亡关系的队列研究  

A COHORT STUDY ON THE RELATIONSHIP BETWEEN ALCOHOL CONSUMPTION AND MORTALITY OF DIGESTIVE TRACT CANCER.

作　　者：范宗华[1] 褚天新 樊宗林 李富忠[3] 易永利 张宣福 杨守勇 马义玲[4] 张惠云 王正书[1] 

机构地区：[1]华西医科大学公共卫生学院,成都610041 [2]四川省什邡县卫生防疫站 [3]四川省卫生防疫站地方病防治研究所 [4]华西医科大学电子计算机中心

出　　处：《现代预防医学》1996年第1期20-22,共3页Modern Preventive Medicine

摘　　要：本研究以四川省什邡县疾病监测点为现场,对35岁以下农民29929人进行了五年的前瞻性队列研究,研究累计饮酒量与消化道肿瘤死亡率的关系。结果显示:不同消化道肿瘤的年龄别死亡率随饮酒等级的增加而增加,饮酒组与不饮酒组相比死亡高峰提前;饮酒与男性食道癌、胃癌、肝癌和女性肝癌死亡关联显著(P<0.01)。在累计饮酒量0、1kg～、125kg～、500kg～的四个等级下:男性肝癌的相对危险度(RR)为1.00、1.04、4.26、3.98;男性胃癌RR为1.00、2.53、3.89、6.28;男性食道癌RR为1.00、1.11、3.84、3.17;女性肝癌RR为1.00、1.00、4.80、3.50。经趋势检验证实饮酒与上述三种癌具有显著的剂量效应关系,P<0.05～0.01。但在男、女两性,均未发现饮酒与肠癌有关联(P>0.05)。A cohort study was conducted in the Disease Surveillence Spot in Sifang county of Shichuan Province to investigate the relationship between the accumulated alcohol consumption and the mortality of the digestive tract cancers, the 29929 farmer aged over 35 years-old were followed up five years. The results show: Age-specific mortality of different cancers increases with the increasments of accumulated alcohol cosumption; Accumulated alcohol consumption was strongly related to the risk of esophageal,stomach cancer in man and liver cancer in both man and woman, and a dose-response relation exists. Compared with non—drinking group, in man,the relative risk (RR) of esophageal cancer is 1.11—3.84, the RR of stomach cancer is 2.53—6.28,the RR of liver cancer is 1.04—4.26;In woman,the RR of liver cancer is 1—4.80. But there was no indication of an association between accumulated alcohol consumption and colonrectal cancer rnortality in both man and woman(P>0.05).

关 键 词：饮酒 消化道肿瘤 队列研究 

分 类 号：R735[医药卫生—肿瘤]