沥青工和焦炉工染色体畸变及血清P21蛋白水平的研究  

STUDYONCHROMOSOMALABERRATIONANDSERUMP21PROTEINLEVELOFCOKEANDPITCHWORKERS

作　　者：贾定武[1] 吴逸明[1] 陈琛[1] 杨廷章 马玉英[1] 徐玉宝[1] 

机构地区：[1]河南医科大学劳动卫生学教研室

出　　处：《癌变．畸变．突变》1996年第2期74-78,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本研究对１１名焦炉工和１１名沥青工染色体畸变及血清Ｐ２１蛋白进行了联合检测，接触组染色体畸变及血清Ｐ２１蛋白水平均显著高于对照组（Ｐ＜０．０１），沥青工和焦炉工染色体畸变无显著住差异（Ｐ＞０．０５），沥青工Ｐ２１蛋白水平显著高于焦炉工（Ｐ＜０．０５），有２名沥青工血清Ｐ２１蛋白用性。染色体畸变与血清Ｐ２１蛋白水平无明显直线相关关系。结果提示，Ｐ２１阳性个体有发生用变的潜在危险，接触多环芳烃类物质可以造成染色体损伤和ｒａｓ基因表达的增强，沥青烟气对Ｐ２１蛋白表达水平的升高有较强的作用。11 cokeworkersand11 pitch workers were concurtently screened by chromosomalaberration and serum P21 oncoprotein,2 of 11 pitch workers were positive for P21 protcin. The chromosomal aberration and P21 protein level of both exposed groups were significantlyhigher than the control,the chromosomal aberration of both exposed groups had no signifi- cantly difference,but the P21 protein level of the pitch workers was significantly highcr thanthat of the coke workers,the sum of chromosomal aberration had no linear correlation withthe corresporlding P21 level.It was suggested that the individuakpositive of serum P21 pro- tein might have remarkably high risk for developing cancer,exposure to PAHs could causechromosomal damage and the enhance of P21 protein,the pitch smoke might have strongereffect on thc enhance of P21 protein.

关 键 词：多环芳烃 RAS癌基因 染色体畸变 沥青工 焦炉工 

分 类 号：R131[医药卫生—劳动卫生]