慢性糜烂性胃炎幽门螺杆菌感染治疗的临床研究  

Clinical study on the eradication of Helicobacter pylori infection in patients with chronic erosive gastritis

作　　者：王泽衍[1] 柏乃运[1] 徐光辉[1] 

机构地区：[1]上海市闸北区中心医院消化科,上海200070

出　　处：《世界感染杂志》2006年第2期142-144,共3页World Journal of Infection

摘　　要：目的 比较雷尼替丁、枸橼酸铋、克拉霉素及呋喃唑酮与奥美拉唑、阿莫西林及甲硝唑两根除方案治疗慢性糜烂性胃炎幽门螺杆菌（Hp）感染的临床疗效。方法116例符合条件的病人随机分成两组，其中A组62例使用雷尼替丁、枸橼酸铋、克拉霉素及呋喃唑酮，即口服雷尼替丁150mg，2次/d，连服8wk；枸橼酸铋110mg、克拉霉素500mg及呋喃唑酮100mg，均为2次/d，连服1wk。另一组为B组，54例使用奥美拉唑20mg，2次/d，连服8wk；阿莫西林1000mg及甲硝唑400mg，均为2次/d，连服1wk，疗程结束后1mo复查胃镜。结果 112例病人（A组62例，B组50例）完成治疗及随访，A组与B组Hp根除率分别为86．7％、86，5％（P〉0．05），糜烂愈合率分别为91．7％、88．5％（P〉0．05），差异均无统计学意义。Hp根除组糜烂愈合率（99．0％）明显高于Hp未根除组（53.3％），有非常显著的统计学差异（P〈0．0001）。不良反应发生率分别为12．9％、14．8％（P〉0．05），差异无统计学意义。结论 两组均有较理想的Hp根除率及糜烂愈合率，不良反应发生率两组相当。Hp根除有利于糜烂愈合。Objective To investigate the effects of the two methods to treat Helicobacter pylori（Hp）infection in patients with chronic erosive gastritis and compare the Hp eradication rates and the side effects of drugs. Methods One hundred and sixteen patients with chronic erosive gastritis, confirmed by endoscopy, with Hp infection （confirmed by 14^C-UBT and pathology）, were divided randomly into two groups： Group A （Ranitidine therapy with 8-week combined with bismuth citrate, clafithromycin and furazolidone with a standard dose of Hp eradication for one week）; Group B （Omeprazole therapy with 8-week combined with amoxicillin plus metronidazole for one week. Results Total 112 patients were included and followed up （Group A=62, Group B=50）. The eradication rates of Hp were 86.7% and 86.5% （P〉0.05） in Group A and Group B, respectively. The erosive healing rates were 99.0% and 53.3% for Hp eradication and failure of Hp eradication group, respectively （P〈0.0001）. There was no difference of the side effects between Group A （12.9%） and Group B （14.8%） （P〉0.05）. Conclusion Group A is the same as Group B in efficacy of Hp eradication, the rates of erosive healing and adverse reaction. Hp eradication may be helpful for erosive healing of chronic gastritis.

关 键 词：慢性(糜烂性)胃炎 幽门螺杆菌 感染 治疗 

分 类 号：R573.3[医药卫生—消化系统]