抗卵巢上皮癌单克隆抗体COC 183 B_2肿瘤免疫显像定位诊断的初步观察  

THE CLINICAL APPLICATION OF MONOCLONAL ANTIBODY COC 183 B_2 IN RADIOIMMUNOIMAGING OF PATIENTS WITH OVARIAN CARCINOMA

作　　者：钱和年[1] 冯捷[1] 崔恒[1] 付天云[1] 韦平[1] 付志云[1] 高博山 秦淑玲[2] 高书明[2] 杨宗宇[2] 

机构地区：[1]北京医科大学人民医院妇科肿瘤研究室 [2]北京医科大学人民医院核医学科

出　　处：《北京医科大学学报》1990年第5期327-330,402,共4页Journal of Peking University(Health Sciences)

摘　　要：用本室制备卵巢癌单克隆抗体COC 183 B_2,按武汉生物制品所治疗用单抗要求;经^(131)I标记,按腹腔及皮下注射,分别应用于13例患者。腹腔注射组中,8例显像情况与手术所见完全符合。3例原发卵巢癌均显像,1例Krukenberg瘤转移卵巢不显像,另4例不显像者均为良性肿瘤;皮下注射组中只1例卵巢粘液性囊腺癌术后化疗后锁骨上淋巴结转移未显像,而瘤组织与COC 183 B_2免疫组化染色亦阴性。T/NT比值5.35～13.7,提示此单抗可用作放免显像、肿瘤定位,鉴别诊断、临床分期及追踪检测等。Monoclonal antibody COC 183 B2 against ovarian carcinoma was prepared in our laboratory andqualified as required for therapeutic use. After ^(131)I labeling COC 183 B2 was injected intraperitoneally(i. p.) or subcutaneously (s. c.) in 2 groups of patients for radioimmunoimaging (RⅡ). 8 cases of i.p. group gave the images all corresponding with the findings during operations: 3 positive images inprimary ovarian carcinomas, 1 negative image in Kruenberg tumor metastatic to ovary and 4 negativeimages all in benign tumors. In the 5 s.c. cases only one mucinous ovarian cystadenocarcinoma aftersurgery and chemotherapy with left supraclavicular lymph node metastasis had a negative image andthe immunohistological staining with COC 183 B_2 was also negative. Computor calculated T/NT duringthe radioimmunoimaging was 5.35 to 13.7. The above results suggest that this MAb could be used forRⅡ, tumor localization, which will be of help to presurgical staging, differential diagnosis as well asfollow-up.

关 键 词：卵巢上皮癌 单克隆抗体 碘131 标记 卵巢肿瘤 

分 类 号：R730.44[医药卫生—肿瘤]