喉癌组织中血管内皮生长因子表达与CD83阳性树突状细胞分布的关系  

Relationship Between CD83 Positive Dendritic Cell and Vascular EndothelialL Growth Factor in Laryngeal Carcinoma

作　　者：陶宇欣[1] 贾立敏[2] 徐玉东[2] 

机构地区：[1]黑龙江省医院耳鼻喉科,黑龙江哈尔滨150036 [2]哈尔滨医科大学解剖教研室,黑龙江哈尔滨150086

出　　处：《黑龙江医学》2006年第3期179-181,共3页Heilongjiang Medical Journal

基　　金：黑龙江省科技攻关课题(GOOC191901)

摘　　要：目的探讨喉癌组织中血管内皮生长因子(VEGF)表达与CD83阳性树突状细胞(DC)分布的关系。方法42例喉癌组织经抗VEGF、抗CD83抗体免疫组化染色,观察喉组织中CD83阳性DC及VEGF分布,以及CD83阳性DC密度与VEGF表达强度的相关性。结果42例肿瘤标本中“-”12例,“+”者14例,“++”者16例。CD83+树突状细胞形态不规则,表面有许多不规则树状突起,主要分布于癌周组织内,趋向于成群分布;偶可见到CD83+DC位于靠近癌周组织的癌巢间间质内。喉癌组织中VEGF的表达明显升高的病例,其CD83+DC密度显著降低。结论VEGF的表达与喉癌组织中CD83+DC含量呈明显的负相关。Objective To investigate the relationship between the expression of vascular endothelial growth factor（VEGF） and CD83^＋ dendritic cell density in human laryngeal carcinoma. Methods 42 laryngeal carcinoma tissues were investi- gated by immunohistochemical studies with anti - VEGF, anti - CD83 antibodies. Results For intensity of VEGF staining, 12 tumors were graded as negative staining, 14 as ＂ ＋ ＂, 16 as ＂ ＋ ＋ ＂; CD83 ^＋ mature DCs were irregular in shape and extended many irregular dendritic protrusions; CD83^＋ mature DCs were confined to peritumoral areas in groups. Sometimes, CD83^＋ DCs were found in stroma among cancer nests nextto peritumoral areas. A close correlation between VEGF and CD83 ^＋ DC density was found in laryngeal carcinoma. An intensive VEGF expression is associated with the lower density DC. Conclusion The result suggests that the density of CD83^＋ DCs in laryngeal carcinoma is negatively related to the expression of VEGF.

关 键 词：肿瘤学 喉癌 树突状细胞 血管内皮生长因子 CD83 

分 类 号：R739.63[医药卫生—肿瘤]