米托蒽醌与柔红霉素治疗急性白血病疗效比较  

Comparative Analysis between Mitoxantrone and Rubomycin for the Curative Effect on Acute Leukemia

作　　者：赵恒[1] 邬国和[1] 李东宁[1] 刘定胜[1] 颜丽华[1] 李萍[1] 

机构地区：[1]南昌大学第三附属医院血液科,南昌330008

出　　处：《江西医学院学报》2006年第2期107-109,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的比较米托蒽醌(mitoxantrone,MIT)和柔红霉素(rubomycin,DNR)治疗急性白血病的疗效与不良反应。方法用随机研究的方法将58例急性白血病患者分为MIT方案组(30例)和DNR方案组(28例)治疗,观察两组的疗效及不良反应。结果MIT组与DNR组的完全缓解率分别为80.0%、53.6%,1疗程完全缓解率分别为66.7%、42.8%,差异均有显著性(P<0.05)。MIT组患者化疗后严重骨髓抑制(IV度)的发生率80.0%高于DNR组的57.1%(P<0.05),骨髓抑制期肺部感染和败血症的发生率30.0%、16.7%亦高于DNR组的10.7%、3.6%(P<0.05)。DNR组脱发的发生率46.4%明显低于MIT组的66.7%(P<0.01),且程度较低。结论对于急性白血病的治疗,MIT为主的联合化疗方案优于DNR为主的联合化疗方案。与MIT方案组相比,DNR方案组的毒副作用较低。Objective To compare the efficacy and adverse effects of mitoxantrone with that of rubomycin in the treatment of acute leukemia. Methods Fifty-eight cases of acute leukemia patients were randomly divided into two groups： MIT and DNR-groups. The efficacy and adverse effects of the two groups were compared. Results The complete remission （CR） rate was 80.0% and 53. 6% in MIT-and DNR-treated groups , respectively. The CR rate in the first course of chemotherapy was 66.7% and 42.8%, respectively. It was significant difference between the two groups（P〈0.05）. The incidence of severe bone marrow depression in MIT group （80. 0%）was higher than that in DNR group（57. 1%）（P〈0.05）. The incidence of pneumonia infection and septicemia in MIT group （30.0% , 16.7%）was higher than that in DNR group （10.7%,3.6%）. The incidence of alopecia in DNR group（46.4%） was significantly lower than that in MIT group （66.7%）（P〈0.01）and its degree was lower. Conclusion The MIT combination chemotherapy regimens are better than DNR ones about their curative effects in acute leukemia therapy. Compared with the MIT regiments, the DNR regiments have lower side effects.

关 键 词：米托蒽醌 柔红霉素 急性白血病 疗效 

分 类 号：R733.71[医药卫生—肿瘤]