Survivin在肾透明细胞癌中的表达及其意义  

Expression of survivin and its significance in suprarenal epithelioma

作　　者：朱李兵[1] 王禾[1] 武国军[1] 王栋[2] 

机构地区：[1]第四军医大学西京医院泌尿外科,陕西西安710032 [2]南京军区福州总医院泌尿外科,福建福州350000

出　　处：《西安交通大学学报（医学版）》2006年第2期186-188,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的检测抗凋亡基因survivin在肾透明细胞癌中的表达情况及其与肾透明细胞癌生物学特性的关系。方法收集53例肾透明细胞癌组织及8例正常肾组织,以免疫组织化学方法检测survivin蛋白表达;半定量RT-PCR方法,检测肾透明细胞癌中survivin mRNA表达水平,与正常肾组织进行比较分析。结果62.3%(33例)肾透明细胞癌组织表达survivin蛋白,而正常肾组织无1例阳性表达。RT-PCR结果表明,survivin mRNA阳性表达率为56.25%(18/32)。Survivin表达与病理分级、临床分期、有无淋巴结转移等恶性生物学特性密切相关。结论Survivin的高表达与肾透明细胞癌具有密切相关性,提示survivin对于肾透明细胞癌的预后可能具有重要意义。Objective To detect the expression of survivin in suprarenal epithelioma（SRE） and elucidate its function in suprarenal epithelioma. Methods A total of 53 SRE specimens and 8 nomal nephridial tissues were obtained, lmmunohistochemistry method was used to test protein expression of survivin. Semi-quantitative RT-PCR was used to measure survivin mRNA levels. Results Survivin protein were detected in 33 of 53 （62.3%） SRE tissues. In contrast, no expression of survivin in nomal nephridial tissues was detected. The expression rate of survivin mRNA in tumor tissues （56. 25%, 18/32） was significantly higher than that in normal tissues （0, 0/8）. Conclusion Over expression of survivin is common in suprarenal epithelioma. Survivin may play an important role in SRE and is associated with prognosis.

关 键 词：肾透明细胞癌 SURVIVIN 凋亡 

分 类 号：R737.11[医药卫生—肿瘤]