神经源性、梗阻性和特发性逼尿肌不稳定模型下离体逼尿肌条收缩特性的对照研究  

Control study of physiological properties of detrusor instability caused by neurogenic, obstructive and idiopathic factors in rats

作　　者：张武合[1] 宋波[1] 方强[1] 陈可[1] 

机构地区：[1]第三军医大学西南医院全军泌尿外科中心,重庆400038

出　　处：《第三军医大学学报》2006年第7期674-676,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目(30371429)~~

摘　　要：目的比较不同原因所致的逼尿肌不稳定(detrusor instability,DI)在逼尿肌自身生理特性方面的改变。方法建立大鼠膀胱流出道梗阻(bladder outlet obstruction,BOO)、脊髓损伤(spinal cord injury,SCI)以及特发性逼尿肌不稳定(idiopathic detrusor instability,IDI)模型,6周后行充盈性膀胱测压及离体逼尿肌条实验。结果成功建立不同DI模型,DI-BOO发生率为75·9%,DI-SCI发生率100%,IDI发生率为21·3%,与正常对照组相比,DI-BOO,DI-SCI和IDI组离体逼尿肌条的自发性收缩频率及收缩幅度均明显增强(P<0·05),而各模型组间相比差异无显著性(P>0·05)。结论不同原因所致的逼尿肌不稳定都有着相似的逼尿肌自身的肌源性特性改变,逼尿肌组织自发性兴奋性增高在逼尿肌不稳定的发生中有着重要作用。Objective To compare the changes of detrusor physiological properties between the models of detrusor instability caused by neurogenic, obstructive and idiopathic factors. Methods Eighty female SD rats were enrolled in our study, including 17 rats of idiopathic detrusor instability （ IDI）, 33 for bladder outlet obstruction （BOO） by partial ligation of bladder outflow tract, 20 spinal cord injury SCI） by transection of spinal cord at L1-2, 10 as normal control. Six weeks after insult, the change of detrusor excitability, autorhythmicity and contractility were examined by means of cystometry and the in vitro detrusor strip study. Results The occurrence rate of detrusor instability in BOO rats, SCI rats and IDI rats was 75.9%, 100% and 21.3%.The rats in three DI groups increased more significantly in excitability, autorhythmicity and contractility than control rats （P 〈 0. 05 ）, while no significant difference was among the rats in three DI groups （ P 〉 0. 05 ）.Conclusion Different types of DI have similarity in the detrusor myogenic changes, while the increase in spontaneous excitability of detrusor strip seems to be more important than others factors in the mechanism of DI.

关 键 词：逼尿肌 逼尿肌不稳定 兴奋性 

分 类 号：R-331[医药卫生] R337.2