D-半乳糖衰老大鼠性腺轴系超微结构的变化  

Ultrastructural changes of gonad axises in D-gal-induced aging rats

作　　者：陈志宏[1] 杜金凯[1] 高福禄[1] 赵淑敏[1] 

机构地区：[1]承德医学院基础医学研究所,承德067000

出　　处：《解剖学杂志》2006年第2期162-166,共5页Chinese Journal of Anatomy

基　　金：河北省科技厅资助(03547003D)

摘　　要：目的:观察D-半乳糖衰老大鼠性腺轴系超微结构的变化。方法:D-半乳糖连续腹腔注射制作亚急性衰老的大鼠模型,应用透射电镜观察模型大鼠下丘脑弓状核、垂体及睾丸超微结构的变化。结果:D-半乳糖衰老大鼠弓状核出现线粒体嵴断裂、粗面内质网脱颗粒、高尔基复合体扩张等变化;垂体促性腺激素细胞出现线粒体嵴断裂、粗面内质网扩张、高尔基复合体扩张等变化,并观察到脱粒细胞;睾丸支持细胞内溶酶体增多,内质网增生、扩张,线粒体嵴断裂,精原细胞可见胞质内出现许多空泡,并观察到了凋亡小体。结论:D-半乳糖衰老大鼠性腺轴系的超微结构发生了明显改变,揭示了D-半乳糖衰老过程中下丘脑垂体性腺轴的重要作用。Objective： To observe the ultrastructural changes of the gonad axises in D-gal-induced aging rats. Methods. The subacute aging rat model was induced by injecting D-gal into the rat＇ abdominal cavity continually. Transmission electron microscope was used to observe the ultrastructural changes of arcuate nucleus in hypothalamus, pituitary and testis of model rats. Results： Obvious changes were observed in gonad axises of aging rats. The neurons of arcuate nucleus in hypothalamus： mitochondrial cristae were fractured, GER was degranulated and Golgi complex was expanded. The gonadotrophs in pituitary： mitochondrial cristae were fractured, GER and Golgi complex was expanded, and degranulation of gonadotrophs were also observed. Testis： In Sertoli cell, endoplasmic reticulum proliferated and was expanded, mitochondrial cristae were fractured and lysosome was increased; many bubbles appeared in spermatogonia cytoplasm and apoptotic bodies were also observed. Conclusion： The ultrastructure of gonad axises of aging rats has obvious changes, indicating the important functions of hypothalamus-pituitary-testis axis during aging.

关 键 词：衰老 超微结构 下丘脑 垂体 睾丸 

分 类 号：R361[医药卫生—病理学]