微小染色体维持蛋白2在乳腺癌组织中的表达及意义  

Expression of minichromosome maintenance protein 2 in breast cancer and its significance

作　　者：杨挚鹰[1] 梁剑平[2] 文建国[3] 陈森林[2] 粟占三[2] 

机构地区：[1]湖南师范大学医学院,长沙410006 [2]湖南省肿瘤医院 [3]中南大学湘雅医学院

出　　处：《解剖学杂志》2006年第2期177-180,共4页Chinese Journal of Anatomy

摘　　要：目的:探讨微小染色体维持蛋白2(MCM2p)在乳腺癌的表达及其与临床病理特征的关系,并分析MCM2p与Ki-67的相关性。方法:运用免疫组织化学方法检测乳腺癌组织中MCM2p、Ki-67的表达。结果:在乳腺癌组织中MCM2p、Ki-67的表达均高于正常乳腺组织,且MCM2p的标记指数明显高于Ki-67,两者表达呈正相关。MCM2p的表达与肿瘤的分化程度、淋巴结转移、临床病理分期和核分裂指数有非常显著相关性,与患者的年龄、肿瘤大小及组织学类型无显著性关系。结论:MCM2p与乳腺癌临床病理的发展紧密相关,作为病理诊断的参考指标较Ki-67有更强的敏感性。Objective： To study the relationship between minichromosome maintenance protein 2 （MCM2p） expression and clinical pathological characteristics of breast cancer, and to analyze the correlation between MCM2p and Ki-67. Methods：The expression of MCM2p and Ki-67 was examined in breast cancer tissue and normal tissues with immunohistochemistry. Results： The expression of MCM2p and Ki-67 was both higher in cancer than those in normal tissues, and the labeling index of MCM2p was higher than that of Ki-67. A positive relationship was found between MCM2p and Ki-67. Labeling index of MCM2p showed significant correlation with the differentiation degree, lymph node status, pathologic stage and mitotic index, but not with patient age, tumor size and histological types. Conclusion： MCM2p has a close correlation with clinic pathological progress of breast cancer and is more sensitive than Ki-67 as an indicator for pathological diagnosis of breast cancer.

关 键 词：微小染色体维持蛋白2 KI-67 乳腺癌 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤] R394[医药卫生—临床医学]