P_(16)抑癌基因在人完全性葡萄胎和正常胎盘组织中的表达  

EXPRESSION OF P16 ANTI-ONCOGENE IN THE VILLI OF HUMAN COMPLETE HYDATIDIFORM MOLE AND NORMAL PLACENTA

作　　者：张晓丽[1] 高英茂[1] 王富武[1] 武玉玲[1] 邴鲁军[1] 李少玲[1] 

机构地区：[1]山东大学医学院组胚教研室,济南250012

出　　处：《中国组织化学与细胞化学杂志》2006年第2期201-203,共3页Chinese Journal of Histochemistry and Cytochemistry

基　　金：教育部高等学校博士学科点专项科研基金(20010422005)

摘　　要：目的研究P16抑癌基因与葡萄胎发生的关系。方法分别取完全性葡萄胎和正常早孕流产标本各30例,用SABC免疫组织化学染色方法,检测P16抑癌基因在两种组织中的表达,并采用图像分析技术,对正常早孕绒毛组和葡萄胎组P16抑癌基因的表达情况进行对比分析。结果与正常绒毛相比,P16抑癌基因在完全性葡萄胎组织中的表达部位和表达量有显著性差异。结论P16抑癌基因与人完全性葡萄胎发生密切相关。Objective To study the relationship between P16 anti-oncogene and the genesis of hydatidiform mole. Methods 30 samples respectively hydatidiform moles and normal early pregnant aborted placenta villi were obtained to detect the P16 anti-oncogene expression in both kinds of tissues by using SABC immunohistochemical staining, and image analysis technology was used to analyse the P16 anti-oncogene - expression in hydatidiform moles and normal villi. Results Compared with that of normal villi, the expression of P16 anti-oncogene was quite different in quantity and location in complete hydatidiform moles. Condusion P16 anti-oncogene has a close relationship with the genesis of human complete hydatidiform mole.

关 键 词：P16抑癌基因 葡萄胎组织 胎盘绒毛 免疫组织化学染色 

分 类 号：R737.33[医药卫生—肿瘤]