卡托普利对糖尿病大鼠早期肾小球血流动力学及血中抗坏血酸消耗的效应  

Effects of captopril on glomerular hemodynamics and blood ascorbate consumption in early diabetic rats

作　　者：朴忠浩 洪天配[1] 王继军[1] 黄大有 卢景 刘宏宇[1] 

机构地区：[1]北京医科大学第三临床医学院,北京医科大学天然药物及仿生药物国家重点实验室

出　　处：《中国糖尿病杂志》1996年第1期31-34,共4页Chinese Journal of Diabetes

基　　金：国家教委博士点基金

摘　　要：观察了Ｃａｐｔｏｐｒｉｌ对ＳＴＺ－糖尿病大鼠肾小球滤过率（ＧＦＲ）、血清中剩余的抗坏血酸（ＲＡ）水平和脂质过氧化物（ＬＰＯ）含量的短期效应。糖尿病组的ＧＦＲ和ＬＰＯ较对照组显著升高，ＲＡ则显著降低；经Ｃａｐｔｏｐｒｉｌ治疗２周后可见上述变化明显被逆转。提示Ｃａｐｔｏｐｒｉｌ对糖尿病早期肾小球血流动力学改变有防止作用，这可能与其具有清除自由基的能力有一定的关系。We observed the short-term effects of captopril on glomerular filtration rate(GFR),serum residual ascorbate(RA)level and lipid peroxide(LPO) value in STZ-induced diabetic rats.Both GFR and LPO were increased while RA was decreased significantly in diabetic rats in comparison with those in control rats.The above changes in diabetic rats were obviously reversed after two weeks of captopril treatment.Our results suggest that captopril may prevent glomerular hemodynamic changes in early diabetics,at least in part by scavenging the free radicals.

关 键 词：糖尿病 卡托普利 肾小球 血流动力学 抗坏血酸 

分 类 号：R587.105[医药卫生—内分泌] R972.4[医药卫生—内科学]