维生素A对沥青烟气诱发小鼠肺癌的阻断作用  

THE INHIBITORY EFFECT OF VITAMIN A ON MOUSE LUNG CANCER INDUCED BY PITCH SMOKE

作　　者：郝志芳[1] 张三申 王江[1] 李欣容[1] 魏丽[1] 

机构地区：[1]河南医科大学病理学教研室,安阳市肿瘤医院病理科

出　　处：《河南医学研究》1996年第1期33-35,38,共4页Henan Medical Research

基　　金：河南省自然科学基金

摘　　要：本实验将１５０只昆明种小鼠随机分为３组（Ａ、Ｂ、Ｃ组）。Ａ、Ｂ组小鼠同时吸入沥青烟气（浓度为１６５．５ｍｇ／ｍ￣３），每天３ｈ，共４个月。Ｂ组小鼠另再维生素Ａ花生油溶液每周灌胃两次，每次０．２ｍｌ（含维生素Ａ醋酸酯７５０Ｕ），至实验结束。Ｃ组为空白对照组。整个实验周期为８个月，其中于实验第３和第６个月时各组均随机处死小鼠６只，最后将剩余动物全部处死．结果：Ａ组肺癌总发生率（７９．２％）明显高于Ｂ组（５５．１％）（Ｐ＜０．０５）。提示，维生素Ａ可有效地阻断由沥青烟气所诱发的肺癌。In this study,150 Kunming mice were divided into three groups,i.e. ,groupA,B and C. All of the mice in group A and B inhaled pitch smoke togather(in a concentrationof 165.5mg/m3)3 hours daily for 4 months. The mice in group B received catheter feeding ofvitamin A acetic ester(750 U in 0.2 ml peanut oil each time)twice a week throughout theexperiment.Group C was designed as a control. The whole experiment lasted 8 months. Sixof the mice in each group were killed at the third and sixth month in the experiment.The restwere killed at the end of the study. The results showed that the incidence of the lung cancerin group A (79.2%)was markedly higher than that in group B (55.1%).It suggest thatvitamin A could effectively inhibit the lung cancer induced by pitch smoke.

关 键 词：维生素A 沥青烟气 肺肿瘤 癌 

分 类 号：R734.201[医药卫生—肿瘤] R977.21[医药卫生—临床医学]